Kent K M, Epstein S E
Cardiology. 1976;61(1):61-74. doi: 10.1159/000169748.
Alterations of autonomic tone appear to have important effects on the electrical stability of the heart. Since altered electrical stability, ventricular fibrillation, is the cause of death in the majority of patients who die from ischemic heart disease, the effects of the autonomic nervous system on ventricular electrical stability have been examined. Increased vagal tone increases the electrical stability of the heart and reduces the incidence of spontaneous ventricular fibrillation after coronary occlusion. These salutary effects of increased cholinergic tone appear to be mediated by cholinergic innervation of the ventricular conducting system. Conversely, increased adrenergic tone decreases the electrical stability of the heart and increases the propensity of the heart to develop ventricular arrhythmias during coronary occlusion. The interaction of the adrenergic and cholinergic system during myocardial ischemia may be one of the important determinants of survival in patients with coronary artery disease and acute myocardial infarction.
自主神经张力的改变似乎对心脏的电稳定性有重要影响。由于电稳定性改变即心室颤动，是大多数死于缺血性心脏病患者的死因，因此已经研究了自主神经系统对心室电稳定性的影响。迷走神经张力增加可提高心脏的电稳定性，并降低冠状动脉闭塞后自发性心室颤动的发生率。胆碱能张力增加的这些有益作用似乎是由心室传导系统的胆碱能神经支配介导的。相反，肾上腺素能张力增加会降低心脏的电稳定性，并增加心脏在冠状动脉闭塞期间发生室性心律失常的倾向。心肌缺血期间肾上腺素能和胆碱能系统的相互作用可能是冠心病和急性心肌梗死患者生存的重要决定因素之一。
