Smith S, Hosid S
Department of Obstetrics and Gynecology, Sinai Hospital of Baltimore, Baltimore, Maryland.
Int J Fertil Menopausal Stud. 1994 Nov-Dec;39(6):316-9.
Immune disturbances are noted in up to 35% of women with premature ovarian failure. Previous investigators have focused on the presence of antibodies directed against steroid secreting cells of the ovary and the presence of lymphocytic infiltration in ovarian biopsy specimens. The authors report two cases of premature ovarian failure associated with antibodies directed against the zona pellucida. One of these two patients conceived while on estrogen replacement therapy.
高达35%的卵巢早衰女性存在免疫紊乱。既往研究人员主要关注针对卵巢类固醇分泌细胞的抗体的存在以及卵巢活检标本中的淋巴细胞浸润情况。作者报告了两例与针对透明带的抗体相关的卵巢早衰病例。这两名患者中的一名在接受雌激素替代治疗期间怀孕。
