Matthews J N
Department of Medical Statistics, University of Newcastle upon Tyne, Medical School, UK.
Stat Methods Med Res. 1994 Dec;3(4):383-405. doi: 10.1177/096228029400300405.
This paper presents a review of crossover designs for use in medical applications which have three or more treatment periods. Only outcomes which can be analysed as continuous variables are considered. Designs which purport to allow for carryover effects are reviewed in detail, as are methods for analysing data collected in such trials. In practice, it is often possible to eliminate carryover by interposing sufficiently long 'washout' periods between successive treatments, and suitable designs for this case are also mentioned. Much current practice revolves around a model which has been widely criticized: the shortcomings of this model and the implications of possible remedies, for design as well as analysis, are discussed.
本文综述了用于具有三个或更多治疗期的医学应用的交叉设计。仅考虑可作为连续变量进行分析的结果。详细综述了旨在考虑残留效应的设计以及此类试验中收集数据的分析方法。在实际操作中，通常可以通过在连续治疗之间插入足够长的“洗脱”期来消除残留效应，本文也提及了适用于这种情况的设计。当前许多实践围绕着一个广受批评的模型展开：讨论了该模型的缺点以及可能的补救措施对设计和分析的影响。
