Teneriello M G, Park R C
Medical College of Pennsylvania.
CA Cancer J Clin. 1995 Mar-Apr;45(2):71-87. doi: 10.3322/canjclin.45.2.71.
Ovarian cancer meets the criteria of a disease for which screening can be justified. The disease is most often diagnosed in advanced stages, when chances for long-term survival are poor. Yet effective treatment exists for early-stage disease, such that early detection can increase long-term survival. However, screening for early-stage ovarian cancer with the high specificity necessary for this low-prevalence disease has proven to be a challenge. This article reviews the issues of early detection of ovarian cancer, including pathology, statistical considerations, diagnostic modalities, and results of the major clinical studies undertaken.
卵巢癌符合可证明进行筛查合理性的疾病标准。该疾病大多在晚期被诊断出来，此时长期生存的几率很低。然而，早期疾病存在有效的治疗方法，因此早期检测可提高长期生存率。然而，事实证明，对这种低患病率疾病进行具有高特异性的早期卵巢癌筛查是一项挑战。本文综述了卵巢癌早期检测的相关问题，包括病理学、统计学考量、诊断方式以及所开展的主要临床研究结果。
