Sen Serhat, Kuru Oğuzhan, Akbayır Ozgür, Oğuz Hilal, Yasasever Vildan, Berkman Sinan
Department of Obstetrics and Gynecology, İstanbul Faculty of Medicine, İstanbul University, İstanbul, Turkey.
Department of Obstetrics and Gynecology, Kanuni Sultan Süleyman Research and Training Hospital, İstanbul, Turkey.
J Turk Ger Gynecol Assoc. 2011 Dec 1;12(4):214-9. doi: 10.5152/jtgga.2011.54. eCollection 2011.
Investigation of serum markers which could be used in the malignancy prediction of adnexal masses.
Vascular endothelial growth factor (VEGF), interleukin 6 (IL-6), leptin, C-reactive protein (CRP), creatine-kinase-MB (CK-MB) and cancer antigen 15-3 (CA 15-3) levels were determined prospectively in serum samples that were obtained from patients who underwent surgery for an adnexal mass and who were referred to Istanbul University, Faculty of Medicine, Department of Obstetrics and Gynecology, between 2009 and 2011, and then were compared with the serum samples of completely healthy outpatient patients as a control group. Based onto the ovarian cancer status, cases were divided into four groups: 13 patients were included in the early-stage malignant group, 12 patients were included in the advanced-stage malignant group, 25 in the benign group and 19 in the healthy control group. Patients with only epithelial ovarian cancer were included into the cancer group. Ethics Commitee approval was obtained for this study. The budget was supported by the Istanbul University Scientific Research Projects Unit.
RESULTS RELATED WITH SENSITIVITY, SPECIFICITY, POSITIVE PREDICTIVE VALUE (PPV), NEGATIVE PREDICTIVE VALUE (NPV) AND ODDS RATIO (OR), RESPECTIVELY, AND THE FOLLOWING VALUES WERE CALCULATED: 48%, 95%, 92%, 59% and +OR 9.6 -OR 0.5 for CA; 15-3; 52%, 75%, 72%, 55%, +OR 2.08 -OR 0.64 for leptin; 72%, 70%, 75%, 66% 2.4-0.5 for IL-6; 24%, 80%, 60%, 45%, 1.2-0.92 for VEGF; 68%, 30%, 55%, 43%, 0.97-1.06 for CRP; and 8%, 70%, 25%, 38%, 026-1.31 for CK-MB.
CA 15-3, IL-6, Leptin, VEGF and CRP were effective in the prediction of benign and malignant masses; however they may be more suitable in selected cases as they have a limited use because of their inadequate potential regarding sensitivity and specificity.
研究可用于附件包块恶性预测的血清标志物。
前瞻性测定2009年至2011年间在伊斯坦布尔大学医学院妇产科接受附件包块手术患者的血清样本中血管内皮生长因子（VEGF）、白细胞介素6（IL - 6）、瘦素、C反应蛋白（CRP）、肌酸激酶同工酶MB（CK - MB）和癌抗原15 - 3（CA 15 - 3）的水平，然后与完全健康的门诊患者血清样本作为对照组进行比较。根据卵巢癌状况，病例分为四组：早期恶性组纳入13例患者，晚期恶性组纳入12例患者，良性组纳入25例患者，健康对照组纳入19例患者。仅上皮性卵巢癌患者纳入癌症组。本研究获得伦理委员会批准。预算由伊斯坦布尔大学科研项目单位提供支持。
分别计算了与敏感性、特异性、阳性预测值（PPV）、阴性预测值（NPV）和比值比（OR）相关的结果，得出以下数值：CA 15 - 3的分别为48%、95%、92%、59%和+OR 9.6 -OR 0.5；瘦素的分别为52%、75%、72%、55%、+OR 2.08 -OR 0.64；IL - 6的分别为72%、70%、75%、66%、2.4 - 0.5；VEGF的分别为24%、80%、60%、45%、1.2 - 0.92；CRP的分别为68%、30%、55%、43%、0.97 - 1.06；CK - MB的分别为8%、70%、25%、38%、0.26 - 1.31。
CA 15 - 3、IL - 6、瘦素、VEGF和CRP在预测良性和恶性包块方面有效；然而，由于它们在敏感性和特异性方面潜力不足，应用有限，可能更适用于特定病例。
