胸腺选择：两条生存之路与两条死亡之路。 - Suppr

Thymic selection: two pathways to life and two to death.

作者信息

Janeway C A

机构信息

Section of Immunobiology, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut 06520-8011.

出版信息

Immunity. 1994 Apr;1(1):3-6. doi: 10.1016/1074-7613(94)90003-5.

DOI:10.1016/1074-7613(94)90003-5

PMID:7889396

Abstract

摘要

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Thymic selection: two pathways to life and two to death.胸腺选择：两条生存之路与两条死亡之路。

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The CD8 coreceptor revisited: one chain good, two chains better.重新审视CD8共受体：单链良好，双链更佳。

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Intracellular signals that mediate thymic negative selection.介导胸腺阴性选择的细胞内信号。

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Programmed death-1 (PD-1):PD-ligand 1 interactions inhibit TCR-mediated positive selection of thymocytes.程序性死亡蛋白1（PD-1）：PD-配体1的相互作用抑制T细胞受体介导的胸腺细胞阳性选择。

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Positive and negative selection of thymocytes depends on Lck interaction with the CD4 and CD8 coreceptors.胸腺细胞的阳性和阴性选择取决于Lck与CD4和CD8共受体的相互作用。

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MHC class II-specific T cells can develop in the CD8 lineage when CD4 is absent.当缺乏CD4时，MHC II类特异性T细胞可在CD8谱系中发育。

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Thymic nurse cells support CD4-CD8+ thymocytes to differentiate into CD4+CD8+ cells.胸腺哺育细胞支持CD4-CD8+胸腺细胞分化为CD4+CD8+细胞。

Cell Mol Immunol. 2005 Aug;2(4):301-5.

Molecular associations between the T-lymphocyte antigen receptor complex and the surface antigens CD2, CD4, or CD8 and CD5.T淋巴细胞抗原受体复合物与表面抗原CD2、CD4或CD8及CD5之间的分子关联。

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Disruption of T lymphocyte positive and negative selection in mice lacking the CD8 beta chain.缺乏CD8β链的小鼠中T淋巴细胞阳性和阴性选择的破坏。

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Discrimination between maintenance- and differentiation-inducing signals during initial and intermediate stages of positive selection.阳性选择初始和中间阶段维持诱导信号与分化诱导信号之间的区分。

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Negative selection of thymocytes expressing the D10 TCR.表达D10 TCR的胸腺细胞的阴性选择。

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Notch1 confers a resistance to glucocorticoid-induced apoptosis on developing thymocytes by down-regulating SRG3 expression.Notch1通过下调SRG3的表达赋予发育中的胸腺细胞对糖皮质激素诱导的细胞凋亡的抗性。

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Paradoxical intrathymic positive selection in mice with only a covalently presented agonist peptide.仅具有共价呈递的激动剂肽的小鼠中反常的胸腺内阳性选择。

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Correlation of the EL-4 lymphoma cell apoptosis with the expression of heat shock proteins.EL-4淋巴瘤细胞凋亡与热休克蛋白表达的相关性

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A functionally essential domain of RFX5 mediates activation of major histocompatibility complex class II promoters by promoting cooperative binding between RFX and NF-Y.RFX5的一个功能必需结构域通过促进RFX与NF-Y之间的协同结合来介导主要组织相容性复合体II类启动子的激活。

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Immunological self/nonself discrimination: integration of self vs nonself during cognate T cell interactions with antigen-presenting cells.免疫自我/非自我识别：在同源T细胞与抗原呈递细胞相互作用过程中自我与非自我的整合。

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Role of heat shock proteins in protection from and pathogenesis of infectious diseases.热休克蛋白在传染病防御及发病机制中的作用。

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Development and function of T cells in T cell antigen receptor/CD3 zeta knockout mice reconstituted with Fc epsilon RI gamma.用FcεRIγ重建的T细胞抗原受体/CD3ζ基因敲除小鼠中T细胞的发育与功能

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Thymic selection: two pathways to life and two to death.

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