早期胃癌患者的生长模式及p53过表达

Growth pattern and p53 overexpression in patients with early gastric cancer.

作者信息

Oiwa H, Maehara Y, Ohno S, Sakaguchi Y, Ichiyoshi Y, Sugimachi K

机构信息

Department of Surgery II, Faculty of Medicine, Kyushu University, Fukuoka, Japan.

出版信息

Cancer. 1995 Mar 15;75(6 Suppl):1454-9. doi: 10.1002/1097-0142(19950315)75:6+<1454::aid-cncr2820751511>3.0.co;2-g.

DOI:10.1002/1097-0142(19950315)75:6+<1454::aid-cncr2820751511>3.0.co;2-g

PMID:7889474

Abstract

BACKGROUND

The growth pattern of early gastric carcinoma, based on a volumetric analysis, reflects well biologic characteristics of the tumor. The penetrating growth (Pen) type tumor has an unfavorable prognosis, compared with a superficially spreading (Super) type. Abnormality of the p53 suppressor gene plays an important role in alteration of cells leading to development of cancer. p53 point mutations are present even in an early stage of carcinoma.

METHOD

In 159 patients with early gastric carcinoma, overexpression of p53 was studied immunohistochemically, using a monoclonal antibody (PAb 1801), and the relationship between growth pattern and p53 overexpression was analyzed.

RESULTS

Early gastric carcinoma was grouped into 43 of the Super type, 37 of the expansively penetrating growth (Pen-A) type, 16 of the infiltratively penetrating growth (Pen-B) type, and 63 of the Small mucosal type limited to the mucosal layer. The Pen-A type tumors were characterized by the highest incidence of p53 positive expression and poorest postoperative course. Between the Pen-A type and the Super type, there were significant differences in the incidence of the p53 positive expression (43% vs. 16%), the frequency of recurrence (16% vs. 7%), and disease free interval (574 days vs. 2926 days).

CONCLUSION

The authors' observations show that the p53 gene plays an important role in expansion of gastric carcinoma, even in the early stages.

摘要

背景

基于容积分析的早期胃癌生长模式能很好地反映肿瘤的生物学特性。与浅表扩散（Super）型相比，浸润性生长（Pen）型肿瘤预后不良。p53抑癌基因的异常在导致癌症发生的细胞改变中起重要作用。即使在癌症早期也存在p53点突变。

方法

对159例早期胃癌患者，采用单克隆抗体（PAb 1801）免疫组化研究p53的过表达情况，并分析生长模式与p53过表达之间的关系。

结果

早期胃癌分为浅表扩散（Super）型43例、膨胀性浸润生长（Pen-A）型37例、浸润性浸润生长（Pen-B）型16例和局限于黏膜层的小黏膜型63例。Pen-A型肿瘤的特点是p53阳性表达发生率最高，术后病程最差。Pen-A型与Super型之间，p53阳性表达发生率（43%对16%）、复发频率（16%对7%）和无病间期（574天对2926天）存在显著差异。