急性非淋巴细胞白血病M4型（髓单核细胞型）中的额外4号等臂染色体与良好预后相关。
Supernumerary isochromosome 4p in ANLL-M4 myelomonocytic type is associated with favorable prognosis.
作者信息
Hoo J J, Gregory S A, Jones B, Szego K
机构信息
Rush Medical Laboratory, Rush Cancer Institute, Division of Hematology & Oncology/Department of Medicine, Chicago, Illinois.
出版信息
Cancer Genet Cytogenet. 1995 Feb;79(2):127-9. doi: 10.1016/0165-4608(94)00125-u.
A case of an acute non-lymphocytic leukemia of M4 type with a supernumerary isochromosome (4p) in 100% of the initial bone marrow metaphase cells is reported. The origin of the extra chromosome is verified by the fluorescence in situ hybridization technique using a whole chromosome 4 painting probe. A possible favorable prognosis of the ANLL-M4 case showing a supernumerary isochromosome (4p) is cautiously emphasized.
报告了1例M4型急性非淋巴细胞白血病，初始骨髓中期细胞100%存在额外的等臂染色体（4p）。使用全染色体4着丝粒探针的荧光原位杂交技术验证了额外染色体的来源。谨慎强调了显示额外等臂染色体（4p）的ANLL-M4病例可能具有良好的预后。
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