Dhawale P J, Wilson D L, Hodgson J M
Division of Cardiology, University Hospitals of Cleveland, Ohio.
Cathet Cardiovasc Diagn. 1994 Dec;33(4):296-307. doi: 10.1002/ccd.1810330403.
Intracoronary ultrasound (ICUS) not only allows visualization of the vessel lumen, it gives a unique view of the transmural components of the artery wall. Analysis of lumen and plaque volume is necessary for studying atherosclerotic disease progression or regression and the mechanisms of therapeutic coronary interventions. A real-time, ICUS pull-back data acquisition scheme was developed to acquire calibrated, cardiac-gated volumetric image data sets. A semiautomated border detection scheme was implemented using dynamic programming. In phantoms, estimated area profiles were very reproducible as measured by the root-mean-square from the mean (3.8-5.9%). In phantom volume estimates, improved reproducibility (standard deviation = 1.2-3.6%) was obtained as positive and negative errors in area profiles were averaged out. Phantom volumes were also accurate when compared to true water displacement volume. The mean error ranged from -2.59 to -8.94%. When compared to quantitative single and biplane angiographic analysis, ICUS volumetric estimates tended to be superior to single plane analysis (error -5.06 +/- 2.48% vs -9.96 +/- 8.01%), but similar to optimal biplane analysis (error -5.06 +/- 2.48% vs -6.34 +/- 3.08%). In vivo reproducibility was assessed by performing multiple cardiac-gated pull-backs through experimentally induced stenosis. Over the length of the stenosis, excellent reproducibility of area profiles (+/- 5.9%) and volumes (+/- 1.9%) was obtained for cardiac-gated acquisitions. We conclude that volumetric ICUS provides accurate and reproducible estimates of lumen volume. Thus this technique may be of use in clinical trials where changes lumen volumes and vessel area profiles are of interest.
冠状动脉内超声（ICUS）不仅能显示血管腔，还能提供动脉壁透壁成分的独特视图。分析管腔和斑块体积对于研究动脉粥样硬化疾病的进展或消退以及治疗性冠状动脉介入的机制是必要的。开发了一种实时ICUS回撤数据采集方案，以获取校准的、心脏门控的容积图像数据集。使用动态规划实施了半自动边界检测方案。在体模中，通过均方根相对于均值测量，估计的面积轮廓具有很高的可重复性（3.8 - 5.9%）。在体模体积估计中，由于面积轮廓中的正误差和负误差相互抵消，获得了更高的可重复性（标准差 = 1.2 - 3.6%）。与真实的水置换体积相比，体模体积也很准确。平均误差范围为 -2.59%至 -8.94%。与定量单平面和双平面血管造影分析相比，ICUS容积估计往往优于单平面分析（误差 -5.06 +/- 2.48%对 -9.96 +/- 8.01%），但与最佳双平面分析相似（误差 -5.06 +/- 2.48%对 -6.34 +/- 3.08%）。通过对实验性诱导的狭窄进行多次心脏门控回撤来评估体内可重复性。在狭窄长度范围内，心脏门控采集的面积轮廓（+/- 5.9%）和体积（+/- 1.9%）具有出色的可重复性。我们得出结论，容积ICUS可提供准确且可重复的管腔体积估计。因此，该技术可能在关注管腔体积和血管面积轮廓变化的临床试验中有用。
