Lindsay J A, Riley T V, Mee B J
Department of Microbiology, University of Western Australia, Queen Elizabeth II Medical Centre, Nedlands.
Eur J Clin Microbiol Infect Dis. 1994 Dec;13(12):1063-6. doi: 10.1007/BF02111829.
The ability to produce siderophore is considered to be a virulence factor for many pathogenic bacteria. To determine if siderophore production by coagulase-negative staphylococci (CNS) was related to virulence, 40 clinical isolates of CNS cultured from peritoneal dialysis fluid were compared with 38 commensal skin isolates. Siderophore activity was detected using the chrome azurol S liquid assay. Using precursor studies, Staphylococcus epidermidis isolates were shown to be more likely to produce the siderophore staphyloferrin A. Production of staphyloferrin B amongst non-Staphylococcus epidermidis species was associated with clinical isolates rather than commensal isolates, and therefore may play a role in pathogenicity.
产生铁载体的能力被认为是许多病原菌的一种毒力因子。为了确定凝固酶阴性葡萄球菌（CNS）产生铁载体是否与毒力相关，将从腹膜透析液中培养的40株CNS临床分离株与38株皮肤共生分离株进行了比较。使用铬天青S液体分析法检测铁载体活性。通过前体研究表明，表皮葡萄球菌分离株更有可能产生铁载体葡萄球菌铁载体A。在非表皮葡萄球菌物种中，葡萄球菌铁载体B的产生与临床分离株而非共生分离株相关，因此可能在致病性中起作用。
