自闭症中的内源性阿片类物质和阿片拮抗剂：实证研究结果简述及其对临床医生的启示
Endogenous opioids and opiate antagonists in autism: brief review of empirical findings and implications for clinicians.
作者信息
Gillberg C
机构信息
Department of Child and Adolescent Psychiatry, University of Göteborg, Annedals Clinics, Sweden.
出版信息
Dev Med Child Neurol. 1995 Mar;37(3):239-45. doi: 10.1111/j.1469-8749.1995.tb11998.x.
Abstract
Endogenous opioid dysfunction hypotheses for the development of autism are reviewed, along with clinical empirical studies of opiate antagonists in autism and self-injurious behaviour. There is not yet sufficient evidence to suggest the use of opiate antagonists in the treatment of autism. Further research, particularly of natrexone in severe self-injury, is warranted.
摘要
本文回顾了关于自闭症发展的内源性阿片类物质功能障碍假说，以及阿片类拮抗剂在自闭症和自伤行为方面的临床实证研究。目前尚无足够证据支持使用阿片类拮抗剂治疗自闭症。有必要进行进一步研究，尤其是针对纳曲酮治疗严重自伤行为的研究。
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