Rizzo A M, Galli C F, Montorfano G, Berra B
Institute of General Physiology and Biochemistry, School of Pharmacy, University of Milan, Italy.
J Neurochem. 1995 Apr;64(4):1728-33. doi: 10.1046/j.1471-4159.1995.64041728.x.
The phospholipid profile of different chick embryo brain regions was studied from 11 to 21 days of development, revealing interesting changes in content and distribution. Total phospholipid phosphorus (P), in micrograms of P per microgram of DNA, increases significantly during development of cerebral hemispheres (CHs), optic lobes (OLs), and brainstem (BS). Compared with CH and OL, the BS shows at all stages a significantly higher concentration of phospholipid P, which in contrast decreases in the cerebellum (CB) during development. Moreover, the data show interesting differences between the right and the left portion of the brain. The distribution of phospholipid P and the fatty acid composition of phospholipids were asymmetric between left and right OL and CH, as were the concentrations of DNA and cholesterol, demonstrating lateralized neurochemical development in these structures, i.e., left OL, right OL, left CH, and right CH. The data are discussed also in relation to the potential importance of neurochemical lateralization for determining lateralized embryonic and postnatal behavior of this species.
对发育11至21天的不同鸡胚脑区的磷脂谱进行了研究，结果揭示了其在含量和分布上有趣的变化。每微克DNA中总磷脂磷（P）的含量（以微克P计）在大脑半球（CH）、视叶（OL）和脑干（BS）的发育过程中显著增加。与CH和OL相比，BS在所有阶段都显示出磷脂P的浓度显著更高，而小脑（CB）在发育过程中磷脂P的浓度则降低。此外，数据显示大脑左右部分之间存在有趣的差异。磷脂P的分布以及磷脂的脂肪酸组成在左右OL和CH之间是不对称的，DNA和胆固醇的浓度也是如此，这表明这些结构（即左OL、右OL、左CH和右CH）存在神经化学的偏侧化发育。还讨论了这些数据与神经化学偏侧化对于确定该物种胚胎期和出生后偏侧化行为的潜在重要性之间的关系。
