Rizzo Angela M, Rossi Federica, Berra Bruno
Institute of General Physiology and Biochemistry, School of Pharmacy, University of Milan, Italy.
Neurochem Res. 2002 Aug;27(7-8):815-21. doi: 10.1023/a:1020213209078.
Glycosphingolipids, in particular gangliosides, play a crucial role in neuronal development and are known to change dramatically in total content and distribution in different brain areas during embryogenesis. In the present work we analyzed the activity of enzymes involved in the metabolism of gangliosides, at different periods of functional maturation in different regions of chick embryo brain. Our data demonstrate differences in the enzymatic activities in the examined areas; these differences might be correlated with the functional lateralization occurring in the brain during development. Significative differences were found in glycosphingolipid composition between controlateral cerebral hemispheres and optic lobes; these results together with previous data we found, contribute to reinforce our hypothesis on the occurrence of biochemical lateralization during early brain development.
糖鞘脂，尤其是神经节苷脂，在神经元发育中起关键作用，并且已知在胚胎发生过程中，其总量和在不同脑区的分布会发生显著变化。在本研究中，我们分析了鸡胚脑不同区域在功能成熟的不同时期参与神经节苷脂代谢的酶的活性。我们的数据表明，在所检查的区域中酶活性存在差异；这些差异可能与发育过程中大脑出现的功能侧化有关。在对侧大脑半球和视叶之间的糖鞘脂组成中发现了显著差异；这些结果与我们之前发现的数据一起，有助于加强我们关于早期脑发育过程中生化侧化发生的假设。
