Egelrud T
Institutionen för dermatologi och venereologi, Hudkliniken, Norrlands Universitetssjukhus, Umeå.
Nord Med. 1995;110(3):76-8, 87.
The aetiology of many skin diseases is to be sought in the multiplicity of interactions between mechanisms generally present in the body, such as the inflammatory response and immune systems, and mechanisms present in the skin. In the case of organ-specific skin diseases, it is reasonable to suppose the underlying disturbance to affect structures and molecular processes unique to the skin. The stratum corneum represents the culmination of epidermal differentiation and consists of very resistant and cohesive cells surrounded by an intracellular space filled with lamellar lipids, thus forming a highly effective and resistant physico-chemical barrier between the interior of the body and the external environment. As the stratum corneum is continuously produced, a prerequisite of its well-regulated thickness is an equally well regulated shedding of cells from the skin surface. This is preceded by proteolytic degradation of intracellular cohesive structures--i.e. desmosomes. We have recently discovered a new serine proteinase, stratum corneum chymotryptic enzyme (SCCE), which may be involved in this process. SCCE has been purified, cloned and expressed in mammalian cells.
许多皮肤病的病因可从机体普遍存在的机制（如炎症反应和免疫系统）与皮肤中存在的机制之间的多种相互作用中探寻。对于器官特异性皮肤病而言，推测潜在的紊乱会影响皮肤特有的结构和分子过程是合理的。角质层代表了表皮分化的顶点，由极具抗性且相互黏附的细胞组成，细胞周围是充满板层脂质的细胞内空间，从而在身体内部与外部环境之间形成了一个高效且有抗性的物理化学屏障。由于角质层是持续产生的，其厚度得到良好调节的一个前提是皮肤表面细胞的脱落也得到同样良好的调节。在此之前会发生细胞内黏附结构（即桥粒）的蛋白水解降解。我们最近发现了一种新的丝氨酸蛋白酶，即角质层胰凝乳蛋白酶（SCCE），它可能参与了这一过程。SCCE已被纯化、克隆并在哺乳动物细胞中表达。
