Lamartiniere C A, Moore J, Holland M, Barnes S
Department of Pharmacology and Toxicology, University of Alabama at Birmingham 35294-0019.
Proc Soc Exp Biol Med. 1995 Jan;208(1):120-3. doi: 10.3181/00379727-208-43843.
We have investigated the potential of genistein, an estrogenic component of soy, when administered neonatally, to manifest a protective effect against chemically induced mammary cancer. Female Sprague-Dawley rats were treated on Day 2, 4, and 6 postpartum with genistein or dimethylsulfoxide (vehicle). To induce mammary carcinogenesis, all animals were subsequently exposed on Day 50 postpartum to dimethylbenz(a)anthracene. Animals treated neonatally with genistein had increased latency and reduced incidence and multiplicity of mammary tumors compared with vehicle-treated animals. Cell differentiation studies in mammary whole mounts revealed that neonatal genistein treatment resulted in decreased numbers of terminal end buds and increased numbers of lobular structures. A precocious maturation of undifferentiated terminal end buds to more differentiated lobules may account for neonatal genistein treatment protecting against chemically induced mammary cancer.
我们研究了大豆中的雌激素成分染料木黄酮在新生期给药时对化学诱导的乳腺癌是否具有保护作用。在产后第2、4和6天，对雌性斯普拉格-道利大鼠用染料木黄酮或二甲基亚砜（赋形剂）进行处理。为了诱导乳腺癌发生，随后在产后第50天让所有动物接触二甲基苯并(a)蒽。与用赋形剂处理的动物相比，新生期用染料木黄酮处理的动物乳腺肿瘤的潜伏期延长，发病率和肿瘤数量减少。对乳腺整装片进行的细胞分化研究表明，新生期用染料木黄酮处理会导致终末芽数量减少，小叶结构数量增加。未分化的终末芽早熟为更分化的小叶可能是新生期用染料木黄酮处理可预防化学诱导的乳腺癌的原因。
