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[近距离放射治疗在儿童膀胱前列腺横纹肌肉瘤治疗策略中的作用]

[The role of brachytherapy in the therapeutic strategy of vesico-prostatic rhabdomyosarcoma in children].

作者信息

Haie-Meder C, Flamant F, Revillon Y, Valayer J, Gruner M, Martelli H, Habrand J L, Terrier-Lacombe M J, Gerbaulet A

机构信息

Service de Curiethérapie, Institut Gustave-Roussy, Villejuif.

出版信息

Ann Urol (Paris). 1994;28(6-7):302-5.

PMID:7893115
Abstract

Because of its ballistic and physical characteristics, brachytherapy (BT) represents the optimal irradiation treatment in pediatric tumors, especially in prostate or bladder rhabdomyosarcoma. In a limited series of 15 children treated with BT (including three patients treated with salvage BT), 8 out of 9 patients surviving with NED benefited from conservative treatment among 12 patients treated with BT as first-line treatment. Sequelae were minimal consisting of one grade I cystitis and one asymptomatic vesical and ureteral reflux. BT allows administration of high doses to limited volumes sparing normal tissues. BT--whenever possible--represents the treatment of choice compared with external radiotherapy. Indications of BT depend on tumor accessibility and size (usually < or = 4 cm).

摘要

由于其弹道学和物理特性,近距离放射治疗(BT)是小儿肿瘤尤其是前列腺或膀胱横纹肌肉瘤的最佳照射治疗方法。在接受BT治疗的15例儿童的有限系列病例中(包括3例接受挽救性BT治疗的患者),在12例接受BT作为一线治疗的患者中,9例无疾病证据存活的患者中有8例受益于保守治疗。后遗症极少,仅1例I级膀胱炎和1例无症状膀胱及输尿管反流。BT能够对有限的体积给予高剂量照射,同时使正常组织免受照射。与外照射放疗相比,BT在任何可能的情况下都是首选治疗方法。BT的适应证取决于肿瘤的可及性和大小(通常≤4 cm)。

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