Haie-Meder Christine, Martelli Hélène, Dumas Isabelle, Mazeron Renaud, Oberlin Odile
Institut Gustave-Roussy, service de curiethérapie, 114, rue Édouard-Vaillant, 94800 Villejuif, France.
Bull Cancer. 2011 May;98(5):549-57. doi: 10.1684/bdc.2011.1356.
Publications on brachytherapy in paediatric malignancies are scarce, limited to expert institutions. Techniques, brachytherapy modalities (low dose-rate, high dose-rate, pulsed dose-rate), doses and indications vary according to centres. The most frequent tumor sites treated with brachytherapy are gynaecological rhabdomyosarcomas, prostate/bladder rhabdomyosarcomas and soft-tissue sarcomas. Brachytherapy advantages are in relation with ballistic properties, allowing a very high dose to the target with normal tissue sparing. This review analyzes brachytherapy techniques and indications according to tumor sites, brachytherapy results and perspectives. This technique requires a muldisciplinary approach.
关于小儿恶性肿瘤近距离放射治疗的出版物很少,仅限于专业机构。技术、近距离放射治疗方式(低剂量率、高剂量率、脉冲剂量率)、剂量和适应症因中心而异。近距离放射治疗最常治疗的肿瘤部位是妇科横纹肌肉瘤、前列腺/膀胱横纹肌肉瘤和软组织肉瘤。近距离放射治疗的优势与弹道特性有关,能够在 sparing正常组织的情况下向靶区给予非常高的剂量。本综述根据肿瘤部位分析近距离放射治疗技术和适应症、近距离放射治疗结果及前景。该技术需要多学科方法。