Wilhelm K, Curtis J, Birkett V, Kenney-Herbert J
Psychiatry Unit, Prince Henry Hospital, Little Bay, New South Wales.
Aust N Z J Psychiatry. 1994 Sep;28(3):453-7. doi: 10.3109/00048679409075873.
The aim of the study was to assess the effects of a number of physical factors on serial total creatine phosphokinase (CK) levels within the first few days of admission to an acute psychiatric ward. Patients (n = 17) who received parenteral injections within 48 hours of admission were compared with those (n = 30) who did not, looking at factors such as method of admission, alcohol use, presence of restraint and serial CK estimations. Those receiving injections had significantly raised CK levels over the first few days post-admission; these levels tended to normalise over 72 hours of admission. A small number of the patients who were given intramuscular injections demonstrated CK levels of over 1000 U/L. It is suggested that where CK levels are elevated, NMS should be excluded on clinical grounds. CK levels should return to normal over the next 72 hours (in the absence of NMS) if there are no further intramuscular injections.
该研究的目的是评估一系列身体因素对入住急性精神科病房头几天内血清总肌酸磷酸激酶（CK）水平的影响。将入院48小时内接受非肠道注射的患者（n = 17）与未接受非肠道注射的患者（n = 30）进行比较，观察诸如入院方式、饮酒情况、是否使用约束措施以及连续CK测定等因素。接受注射的患者在入院后的头几天CK水平显著升高；这些水平在入院72小时后趋于正常。少数接受肌肉注射的患者CK水平超过1000 U/L。建议在CK水平升高时，应根据临床情况排除神经肌肉阻滞剂所致恶性综合征（NMS）。如果没有进一步的肌肉注射，在接下来（不存在NMS的）72小时内CK水平应恢复正常。
