Peschel O, Kurtz G, Müller-Felber W, Modell S
Psychiatrische Klinik, Universität München.
Nervenarzt. 1994 Oct;65(10):718-21.
We report on the case of a 24 year old female patient, who, at first developed during 8 weeks of neuroleptic therapy parkinsonism and then, after improvement of psychopathology an acute rhabdomyolysis. Hyper-Ck-aemia up to 11,340 U/l was observed. Laboratory parameters normalized shortly after neuroleptics had been withdrawn and no further complications followed. Symptomatology is discussed with special reference to the possibility of an abortive malignant neuroleptic syndrome.
我们报告了一名24岁女性患者的病例,该患者在接受8周抗精神病药物治疗期间首先出现帕金森症,然后在精神病理学症状改善后出现急性横纹肌溶解症。观察到肌酸激酶(CK)血症高达11340 U/l。在停用抗精神病药物后不久,实验室参数恢复正常,且未出现进一步并发症。结合可能的顿挫型恶性抗精神病药物综合征对症状进行了讨论。