Sermet A, Aybak M, Ulak G, Güzel C, Denli O
Department of Physiology, Medical Faculty of Dicle University, Diyarbakir, Turkey.
Arzneimittelforschung. 1995 Jan;45(1):19-21.
Effect of vitamin B6 (pyridoxine-HCl, CAS 58-56-0) on platelet aggregation, plasma lipids and serum zinc level was investigated. The trial comprised 24 healthy male volunteers, aged between 19-24 years. The subjects were randomized in two groups of 12 and treated for 4 weeks by a single daily oral dose of 5 mg/kg vitamin B6 or placebo. Pyridoxine inhibited ADP- or epinephrine-induced aggregation by 48% and 41% (p < 0.001), respectively, whereas there was no change in control group. No significant effect on either, bleeding time, coagulation time or on platelet count was demonstrated in subjects given placebo. Pyridoxine prolonged both bleeding and coagulation time but not over the physiological limits. It had no effect on platelet count. These observations strongly suggest that vitamin B6, with no effect on platelet count, not only inhibits platelet aggregation but also prolongs clotting time. Pyridoxine significantly reduced total plasma lipid and cholesterol levels, whereas it enhanced HDL-cholesterol level. Serum zinc level was also significantly increased by pyridoxine (p < 0.001). These findings suggest that oral vitamin B6 inhibits platelet aggregation in normal subjects.
研究了维生素B6（盐酸吡哆醇，CAS 58-56-0）对血小板聚集、血脂和血清锌水平的影响。该试验包括24名年龄在19至24岁之间的健康男性志愿者。受试者被随机分为两组，每组12人，每天口服5mg/kg维生素B6或安慰剂，治疗4周。吡哆醇分别抑制ADP或肾上腺素诱导的聚集48%和41%（p<0.001），而对照组无变化。给予安慰剂的受试者在出血时间、凝血时间或血小板计数方面均未显示出显著影响。吡哆醇延长了出血和凝血时间，但未超过生理极限。它对血小板计数没有影响。这些观察结果强烈表明，维生素B6在不影响血小板计数的情况下，不仅抑制血小板聚集，还延长凝血时间。吡哆醇显著降低了总血浆脂质和胆固醇水平，同时提高了高密度脂蛋白胆固醇水平。吡哆醇还显著提高了血清锌水平（p<0.001）。这些发现表明，口服维生素B6可抑制正常受试者的血小板聚集。
