Kelsey J E, Arnold S R
Department of Psychology, Bates College, Lewiston, Maine 04240.
Behav Neurosci. 1994 Dec;108(6):1119-27. doi: 10.1037//0735-7044.108.6.1119.
Small lesions of the dorsomedial amygdala reduced the magnitude of the conditioned place aversion produced by naltrexone-precipitated morphine withdrawal, whereas large lesions of the ventral nucleus accumbens had no effect. This finding that the dorsomedial amygdala, which has not been implicated in opiate reward, is involved in mediating the aversiveness of opiate withdrawal is consistent with data indicating that amygdala lesions reduce the aversiveness of a variety of aversive events. In contrast, the nucleus accumbens, which is involved in mediating the rewarding effects of opiates, does not appear to be critically involved in mediating the aversive effects of opiate withdrawal. Together, these findings suggest that the neural structures that mediate the rewarding effects of opiates may be at least partially distinct from the structures that mediate the aversive effects of opiate withdrawal.
杏仁核背内侧的小损伤降低了纳曲酮诱发的吗啡戒断所产生的条件性位置厌恶的程度，而伏隔核腹侧的大损伤则没有效果。这一发现，即尚未涉及阿片类奖赏的杏仁核背内侧参与介导阿片类戒断的厌恶感，与表明杏仁核损伤会降低各种厌恶事件的厌恶感的数据一致。相比之下，参与介导阿片类奖赏作用的伏隔核似乎并不关键地参与介导阿片类戒断的厌恶作用。总之，这些发现表明，介导阿片类奖赏作用的神经结构可能至少部分不同于介导阿片类戒断厌恶作用的结构。
