酿酒酵母中精氨酸生物合成的调控：鸟氨酸氨甲酰基转移酶合成的顺式显性组成型突变体的分离。
Regulation of arginine biosynthesis in Saccharomyces cerevisiae: isolation of a cis-dominant, constitutive mutant for ornithine carbamoyltransferase synthesis.
作者信息
Messenguy F
出版信息
J Bacteriol. 1976 Oct;128(1):49-55. doi: 10.1128/jb.128.1.49-55.1976.
Abstract
A cis-dominant mutation linked to argF, the structural gene specifying ornithine carbamoyltransferase, and affecting the control of the synthesis of this enzyme has been obtained. The level of ornithine carbamoyltransferase in this mutation is depressed and less repressible by addition of L-arginine than it is in the wild-type strain. Of 38 tetrads analyzed, resulting from a cross of a strain harboring this mutation with a strain carrying an argF- mutation, none was a tetratype or a nonparental ditype. This operator mutation helps to define a negative mode of control of the synthesis of the arginine biosynthetic enzymes, as had been suggested earlier upon the isolation of argRI- (arg80), argRII- (arg81), and argRIII- (arg82) specific regulatory mutations.
摘要
已获得一种与argF相关的顺式显性突变，argF是指定鸟氨酸氨甲酰基转移酶的结构基因，该突变影响这种酶合成的调控。与野生型菌株相比，这种突变中鸟氨酸氨甲酰基转移酶的水平降低，添加L-精氨酸后其可抑制性也较低。在对38个四分体进行分析时，这些四分体来自携带此突变的菌株与携带argF突变的菌株杂交，结果没有一个是四型或非亲二型。正如早期在分离argRI-（arg80）、argRII-（arg81）和argRIII-（arg82）特异性调控突变时所暗示的那样，这种操纵子突变有助于确定精氨酸生物合成酶合成的负调控模式。
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