在酿酒酵母中，鸟氨酸氨甲酰基转移酶产生的特异性和“一般性”调控发生在转录水平的证据。
Evidence that specific and "general" control of ornithine carbamoyltransferase production occurs at the level of transcription in Saccharomyces cerevisiae.
作者信息
Messenguy F, Cooper T G
出版信息
J Bacteriol. 1977 Jun;130(3):1253-61. doi: 10.1128/jb.130.3.1253-1261.1977.
Abstract
Ornithine carbamoyltransferase synthesis is subject to two major regulatory systems in Saccharomyces cerevisiae. One system is specific for the arginine biosynthetic enzymes, whereas the other appears to be general, acting on a variety of other amino acid pathways as well. We observed that the synthetic capacity for continued ornithine carbamoyltransferase synthesis had the same short half-life (ca. 5 to 7 min) whether repression of enzyme production was brought about by action of the specific or general control system. We present evidence suggesting that both control systems regulate accumulation or ornithine carbamoyltransferase-specific synthetic capacity, rather than modulating its expression.
摘要
在酿酒酵母中，鸟氨酸氨甲酰基转移酶的合成受两个主要调控系统的控制。一个系统专门针对精氨酸生物合成酶，而另一个系统似乎具有普遍性，也作用于多种其他氨基酸途径。我们观察到，无论酶产生的阻遏是由特定控制系统还是通用控制系统的作用引起的，持续合成鸟氨酸氨甲酰基转移酶的合成能力都具有相同的短半衰期（约5至7分钟）。我们提供的证据表明，这两个控制系统都调节鸟氨酸氨甲酰基转移酶特异性合成能力的积累，而不是调节其表达。
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