Nenoff P, Haustein U F, Münzberger C
Department of Dermatology, University of Leipzig, Germany.
Dermatology. 1995;190(1):48-50. doi: 10.1159/000246634.
The in vitro antifungal activity of lithium succinate has been evaluated against 46 different Malassezia furfur strains, isolated from patients suffering from dandruff, seborrheic dermatitis, and pityriasis versicolor.
Minimum inhibitory concentrations of lithium succinate were measured by the agar dilution technique.
Lithium succinate was found to be able to inhibit growth of all investigated M. furfur isolates in vitro but at much higher concentrations than those which are normally used for susceptibility testing. Minimum inhibitory concentrations between 1,250 and 10,000 micrograms/ml were determined. When compared to the 8% lithium succinate ointment, the investigated concentrations are even far below this 8% value.
It is suggested that the effect of lithium succinate ointment in seborrheic dermatitis therapy in vivo may be at least partly due to an antifungal activity of the agent.
评估琥珀酸锂对从患有头皮屑、脂溢性皮炎和花斑糠疹的患者中分离出的46种不同糠秕马拉色菌菌株的体外抗真菌活性。
采用琼脂稀释技术测定琥珀酸锂的最低抑菌浓度。
发现琥珀酸锂能够在体外抑制所有研究的糠秕马拉色菌分离株的生长，但所需浓度远高于通常用于药敏试验的浓度。测定的最低抑菌浓度在1250至10000微克/毫升之间。与8%琥珀酸锂软膏相比，所研究的浓度甚至远低于这一8%的值。
提示琥珀酸锂软膏在脂溢性皮炎体内治疗中的作用可能至少部分归因于该药物的抗真菌活性。
