Aynaud O, Tranbaloc P
Unité d'urologie-andrologie, Hôpital Saint-Jacques, Paris.
Contracept Fertil Sex. 1995 Feb;23(2):127-30.
There are several possible protocols for the treatment of ano-genital condylomata. In this study, the efficacy of podophyllotoxin (0.5%) was assessed. The authors observed a recovery rate at 1 month of 81% in cases of condylomata of the balano-preputial and vulvar mucous membranes, a rate of 67% in condylomata of the keratinized tissues and 63% in those of the anal margin. Response to treatment is also dependent on the morphology of the lesion; regression was observed in 78% of cases of condylomata acuminata and in 57% of cases of endophytic condylomata. The side effects were local and consisted of erosion in 20% of cases. The efficacy of treatment was, amongst other things, analysed according to the recurrence of the infection at one month, which occurred in 16% of cases affecting mucous membranes. In the therapeutic arsenal for the treatment of condylomata, podophyllotoxin 0.5% is a first line treatment for condylomata acuminata of the genital mucous membranes.
治疗肛门生殖器尖锐湿疣有几种可能的方案。在本研究中，评估了鬼臼毒素（0.5%）的疗效。作者观察到，阴茎头包皮和外阴黏膜尖锐湿疣患者1个月时的治愈率为81%，角化组织尖锐湿疣患者的治愈率为67%，肛门边缘尖锐湿疣患者的治愈率为63%。治疗反应也取决于病变的形态；尖锐湿丘疹患者的治愈率为78%，内生型尖锐湿疣患者的治愈率为57%。副作用为局部性，20%的病例出现糜烂。治疗效果还根据1个月时感染复发情况进行分析，影响黏膜的病例中有16%出现复发。在尖锐湿疣的治疗手段中，0.5%的鬼臼毒素是治疗生殖器黏膜尖锐湿疣的一线治疗药物。
