Bazex J, Garigue J
Service Dermatologie, Hôpital Purpan, Toulouse.
Bull Acad Natl Med. 1994 Oct;178(7):1245-56.
The effects of different drugs on the sebaceous gland is described by the use of an animal model. A castrated rat Wistar was made hyperseborrheic with implant of testosterone. On this model, graduated by a different anti androgen (acetate of cyproterone), anti-seborrheic effect is measured, bound or not the antiandrogenic effect of retinoids, cimetidine, spironolactone and, minoxidil. Retinoids reduced the surface of sebaceous glands but did not express an anti-androgenic effect. Cimetidine and spironolactone presented the same action. Minoxidil had no effect on this model.
通过动物模型描述了不同药物对皮脂腺的作用。将去势的Wistar大鼠植入睾酮使其出现皮脂溢。在该模型上，使用不同的抗雄激素药物（醋酸环丙孕酮）进行分级，测量其抗皮脂溢作用，同时考察维甲酸、西咪替丁、螺内酯和米诺地尔的抗雄激素作用是否存在。维甲酸可减小皮脂腺的表面积，但不表现出抗雄激素作用。西咪替丁和螺内酯表现出相同的作用。米诺地尔对该模型无作用。
