交感神经对犬天然冠状动脉侧支循环的影响。

Sympathetic influences on the native canine coronary collateral circulation.

作者信息

Euler D E

机构信息

Department of Physiology, Loyola University Medical Center, Maywood, IL 60153.

出版信息

Cardiovasc Res. 1995 Jan;29(1):33-7.

PMID:7895236

Abstract

OBJECTIVE

The aim was to investigate the influence of the sympathetic nervous system on the native collateral circulation in the intact heart.

METHODS

Experiments were performed on 10 open chest dogs anaesthetised with alpha chloralose. The left anterior descending coronary artery was cannulated and embolised with 25 microns microspheres. Collateral resistance was determined from measurements of aortic pressure and retrograde flow. Additional haemodynamic measurements included left ventricular pressure and blood flow in the circumflex coronary artery.

RESULTS

Coronary embolisation decreased retrograde resistance from 41.5(SEM 6.0) to 20.1(1.9) mm Hg.ml-1.min-1 (P < 0.01). Left stellate stimulation for 60 s (10 Hz) significantly increased circumflex blood flow and decreased circumflex resistance from 2.1(0.3) to 1.6(0.2) mm Hg.ml-1.min-1. Retrograde resistance during sympathetic stimulation decreased from 19.7(1.8) mm Hg.ml-1.min-1 (P < 0.01). Transient occlusion of descending aorta resulted in changes in perfusion pressure and retrograde flow that were similar to those observed during stellate stimulation. Stellate stimulation after beta blockade with timolol (0.1 mg.kg-1) increased circumflex resistance from 1.9(0.2) to 2.3(0.3) mm Hg.ml-1.min-1 (P < 0.01) but did not alter retrograde resistance.

CONCLUSIONS

The sympathetic nervous system does not have a direct effect on native coronary collateral vessels. Increased sympathetic input to the heart does not result in a coronary steal phenomenon. The primary determinant of flow and resistance in the native collateral network during sympathetic activation is the arterial perfusion pressure.

摘要

目的

研究交感神经系统对完整心脏中天然侧支循环的影响。

方法

对10只用α-氯醛糖麻醉的开胸犬进行实验。将左冠状动脉前降支插管并用25微米的微球栓塞。通过测量主动脉压力和逆行血流来确定侧支阻力。其他血流动力学测量包括左心室压力和左旋支冠状动脉血流量。

结果

冠状动脉栓塞使逆行阻力从41.5（标准误6.0）降至20.1（1.9）mmHg·ml⁻¹·min⁻¹（P<0.01）。左星状神经节刺激60秒（10赫兹）显著增加左旋支血流量，并使左旋支阻力从2.1（0.3）降至1.6（0.2）mmHg·ml⁻¹·min⁻¹。交感神经刺激期间的逆行阻力从19.7（1.8）mmHg·ml⁻¹·min⁻¹下降（P<0.01）。降主动脉短暂闭塞导致灌注压力和逆行血流的变化与星状神经节刺激时观察到的变化相似。用噻吗洛尔（0.1mg·kg⁻¹）进行β受体阻断后星状神经节刺激使左旋支阻力从1.9（0.2）升至2.3（0.3）mmHg·ml⁻¹·min⁻¹（P<0.01），但未改变逆行阻力。