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Inhibition of mitochondrial ATPase by dicarbopolyborate, a new enzyme inhibitor.

作者信息

Drahota Z, Mares V, Rauchová H, Saf P, Kalous M

机构信息

Institute of Physiology, Academy of Sciences, Prague, Czech Republic.

出版信息

J Bioenerg Biomembr. 1994 Oct;26(5):583-6. doi: 10.1007/BF00762743.

DOI:10.1007/BF00762743
PMID:7896773
Abstract

Polyborate anions were found to inhibit mitochondrial ATPase. Mercapto and chloro derivatives of dicarbononaborates showed full inhibition of the enzyme activity at 0.5-0.8 mM. The inhibitory effect of dodecaborates was lower. The inhibition was of competitive type with respect to ATP. The inhibition of soluble F1-ATPase indicates a direct interaction of the polyborate anion with the catalytic part of the enzyme molecule.

摘要

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本文引用的文献

1
Determination of organic phosphorus compounds by phosphate analysis.通过磷酸盐分析测定有机磷化合物
Methods Biochem Anal. 1956;3:1-22. doi: 10.1002/9780470110195.ch1.
2
An electron-transport system associated with the outer membrane of liver mitochondria. A biochemical and morphological study.与肝线粒体外膜相关的电子传递系统。一项生化与形态学研究。
J Cell Biol. 1967 Feb;32(2):415-38. doi: 10.1083/jcb.32.2.415.
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Conversion of biomembrane-produced energy into electric form. I. Submitochondrial particles.生物膜产生的能量向电形式的转化。I. 亚线粒体颗粒。
Biochim Biophys Acta. 1970 Aug 4;216(1):1-12. doi: 10.1016/0005-2728(70)90153-2.
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Membrane potential generation by two reconstituted mitochondrial systems: liposomes inlayed with cytochrome oxidase or with ATPase.由两个重构的线粒体系统产生膜电位：镶嵌有细胞色素氧化酶或ATP酶的脂质体。
Biochim Biophys Acta. 1972 Sep 20;275(3):485-90. doi: 10.1016/0005-2728(72)90233-2.
5
Studies of the energy-transfer system of submitochondrial particles. 2. Effects of oligomycin and aurovertin.亚线粒体颗粒能量转移系统的研究。2. 寡霉素和金褐霉素的作用。
Eur J Biochem. 1968 Feb;3(4):391-400. doi: 10.1111/j.1432-1033.1967.tb19542.x.
6
Conversion of biomembrane-produced energy into electric form. II. Intact mitochondria.生物膜产生的能量向电形式的转化。II. 完整的线粒体。
Biochim Biophys Acta. 1970 Aug 4;216(1):13-21. doi: 10.1016/0005-2728(70)90154-4.
7
Regulation of glycerol 3-phosphate oxidation in mitochondria by changes in membrane microviscosity.通过膜微粘度变化对线粒体中3-磷酸甘油氧化的调节。
FEBS Lett. 1986 Sep 29;206(1):1-3. doi: 10.1016/0014-5793(86)81328-x.
8
Membrane lateral pressure as a modulator of glycerol-3-phosphate dehydrogenase activity.膜侧向压力作为甘油-3-磷酸脱氢酶活性的调节剂
FEBS Lett. 1990 Oct 1;271(1-2):165-8. doi: 10.1016/0014-5793(90)80398-3.
9
Accumulation of boron-10 (10B) in cell cultures exposed to mercaptododecaborate (Na2H(11)10B12SH) used for the neutron capture therapy of brain tumors.用于脑肿瘤中子俘获治疗的巯基十二硼酸盐（Na2H(11)10B12SH）作用下细胞培养物中硼-10（10B）的积累。
J Pharmacol Exp Ther. 1992 Aug;262(2):818-22.
10
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