Borres M P, Odelram H, Irander K, Kjellman N I, Björkstén B
Department of Pediatrics, University Hospital, Faculty of Health Sciences, Linköping University, Sweden.
J Allergy Clin Immunol. 1995 Mar;95(3):694-8. doi: 10.1016/s0091-6749(95)70174-5.
We tested the hypothesis that eosinophilia in peripheral blood and nasal mucosa of infants is an early sign of allergic disease.
The appearance of eosinophilic leukocytes in peripheral blood and nasal mucosa was studied prospectively in 67 infants up to 18 months of age, with or without a family history of atopy.
Eosinophilia was associated with simultaneous presence or subsequent development of atopic disease at 3, 9, and 18 months of age, but not significantly so at 6 months. At 3 months children in whom atopic disease developed later during the observation period had significantly higher numbers of blood eosinophils than children without atopy (p < 0.01). Thus pronounced eosinophilia (> 7 x 10(8) cells/L) at that age was associated with moderate or severe allergic disease during the 18-month observation period. These children continued to have eosinophilia throughout the follow-up period. Blood eosinophilia at 3 months of age also correlated significantly to cord blood IgE levels and to skin prick test reactivity later during the follow-up period. Nasal eosinophilia was a common finding and therefore had little diagnostic or predictive value.
Elevated eosinophil counts in peripheral blood of apparently healthy infants at 3 months of age is associated with a subsequent diagnosis of atopic disease.
我们检验了这样一个假设，即婴儿外周血和鼻黏膜中的嗜酸性粒细胞增多是过敏性疾病的早期迹象。
对67名18个月龄及以下、有或无特应性家族史的婴儿外周血和鼻黏膜中嗜酸性白细胞的出现情况进行了前瞻性研究。
嗜酸性粒细胞增多与3个月、9个月和18个月龄时特应性疾病的同时存在或随后发生相关，但在6个月时无显著相关性。在3个月时，在观察期后期发生特应性疾病的儿童血液嗜酸性粒细胞数量显著高于无特应性的儿童（p<0.01）。因此，该年龄时明显的嗜酸性粒细胞增多（>7×10⁸细胞/L）与18个月观察期内的中度或重度过敏性疾病相关。这些儿童在整个随访期内持续存在嗜酸性粒细胞增多。3个月龄时的血液嗜酸性粒细胞增多也与脐血IgE水平以及随访期后期的皮肤点刺试验反应性显著相关。鼻黏膜嗜酸性粒细胞增多是常见现象，因此诊断或预测价值不大。
3个月龄时表面健康的婴儿外周血嗜酸性粒细胞计数升高与随后的特应性疾病诊断相关。
