Serebrianskaia M V
Klin Med (Mosk). 1994;72(6):40-2.
The author shows that persistent contamination of the mucosa in ulcer patients noticeable even after ulcer healing with Helicobacter pylori leads to disordered coordination of energetic processes in immunocompetent cells. The reserve pathway becomes more active than basic pathway of oxidation, this combining with lymphocyte sensitization to the mucosal tissue. An unfavourable prognostic implication is given to a 1.5-fold inhibition of lymphocyte succinate dehydrogenase activity. If alpha-glycerophosphate dehydrogenase is 2.3 times higher than normal and leukocyte migration index is under 0.65, the prognosis is also likely to be unfavourable.
作者表明，溃疡患者黏膜的持续性污染（即使在溃疡愈合后幽门螺杆菌感染仍很明显）会导致免疫活性细胞能量代谢过程的协调紊乱。备用途径比基本氧化途径更活跃，这与淋巴细胞对黏膜组织的致敏作用相关。淋巴细胞琥珀酸脱氢酶活性受到1.5倍的抑制预示着不良预后。如果α-甘油磷酸脱氢酶比正常水平高2.3倍且白细胞迁移指数低于0.65，预后也可能不佳。
