Underwood J C
J Pathol. 1976 Oct;120(2):75-82. doi: 10.1002/path.1711200203.
The morphology and interactions of lymphoreticular cells in cultures of human tumour tissue was studied by transmission and surface scanning electron microscopy. Macrophages are very common in non-lymphoid neoplasms and vary considerably in shape and surface morphology, with features of mature stimulated cells. Lymphocytes adhere to macrophages more often than to tumour cells. Close contact between macrophages and tumour cells also occurs, but there is no evidence that the infiltrating macrophages or lymphocytes have an overt cytotoxic effect under these cultural conditions. A variety of interactions are seen in cultures of Hodgkin's lymphoma, lymphosarcoma and reticulum cell sarcoma. The only cultural characteristics that may be specific for lymphoma tissue are large intravacuolar collections of lymphocytes within macrophages or giant cells and the rare close spatial relationship between lymphocytes and degenerate macrophages, the latter particularly in Hodgkin's lymphoma. These observations demonstrate the disturbed cellular interrelationships that exist in lymphoma tissue.
利用透射电子显微镜和表面扫描电子显微镜研究了人肿瘤组织培养物中淋巴网状细胞的形态及相互作用。巨噬细胞在非淋巴样肿瘤中非常常见，其形状和表面形态差异很大，具有成熟受刺激细胞的特征。淋巴细胞与巨噬细胞的黏附比与肿瘤细胞的黏附更常见。巨噬细胞与肿瘤细胞之间也会发生紧密接触，但没有证据表明在这些培养条件下浸润的巨噬细胞或淋巴细胞具有明显的细胞毒性作用。在霍奇金淋巴瘤、淋巴肉瘤和网状细胞肉瘤的培养物中可见多种相互作用。可能对淋巴瘤组织具有特异性的唯一培养特征是巨噬细胞或巨细胞内大的淋巴细胞空泡内聚集，以及淋巴细胞与退化巨噬细胞之间罕见的紧密空间关系，后者尤其在霍奇金淋巴瘤中。这些观察结果证明了淋巴瘤组织中存在的细胞间关系紊乱。
