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非霍奇金淋巴瘤的电子显微镜检查

Electron microscopy in the non-Hodgkin's lymphomata.

作者信息

Henry K

出版信息

Br J Cancer Suppl. 1975 Mar;2:73-93.

PMID:1101937
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2149586/
Abstract

The component cells of peripheral lymphoid tissue have been divided into the lymphocyte and plasma cell lines, mononuclear phagocytic cells, dendritic "reticular cells", the reticular (supporting) cells and endothelial cells, and it is suggested that this system of cells should collectively be referred to as the lymphoreticular monoclear phagocyte system or LRMPS. Seventeen tumours of the LRMPS (excluding Hodgkin's disease) have been studied at ultrastructural level. Of these 17 non-Hodgkin lymphomata 5 were follicular lymphomata and 12 diffuse. It is concluded that electron microscopy plays a valuable role in the diagnosis of this group of tumours. Not only does it allow rejection of a diagnosis of lymphoma in certain anaplastic tumours, but it also enables a more precise identification of the cellular components of a lymphoma as well as indicating the degree of differentiation of the cell line involved. Additional advantages are the visualization of subcellular structures useful as markers, and by means of specialized immunoelectron microscopic techniques the identification of antigens and antibody formation within a given tumour. Two other results of this ultrastructural study are the indication that the dendritic cells of lymphoid follicles are derived from capillary endothelium, and the identification of certain anomalous formations derived from rough endoplasmic reticulum in the case of tumours showing plasmacytoid differentiation.

摘要

外周淋巴组织的组成细胞已被分为淋巴细胞系和浆细胞系、单核吞噬细胞、树突状“网状细胞”、网状（支持性）细胞和内皮细胞，有人建议这一细胞系统应统称为淋巴网状单核吞噬细胞系统或LRMPS。已在超微结构水平上研究了17例LRMPS肿瘤（不包括霍奇金病）。在这17例非霍奇金淋巴瘤中，5例为滤泡性淋巴瘤，12例为弥漫性淋巴瘤。得出的结论是，电子显微镜在这组肿瘤的诊断中发挥着重要作用。它不仅能在某些间变性肿瘤中排除淋巴瘤的诊断，还能更精确地识别淋巴瘤的细胞成分，并指出所涉及细胞系的分化程度。其他优点包括可观察到作为标志物的亚细胞结构，以及通过专门的免疫电子显微镜技术识别特定肿瘤内的抗原和抗体形成。这项超微结构研究的另外两个结果是，表明淋巴滤泡的树突状细胞起源于毛细血管内皮，以及在显示浆细胞样分化的肿瘤病例中识别出某些源自粗面内质网的异常结构。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b97/2149586/f2880fc1506a/brjcancersuppl00060-0098-a.jpg
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引用本文的文献

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Quantitative analysis of non-Hodgkin's lymphoma.非霍奇金淋巴瘤的定量分析
J Clin Pathol. 1982 Feb;35(2):135-8. doi: 10.1136/jcp.35.2.135.
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Immunoblastic sarcoma of the B-cell type in the CSF. Light- and electronmicroscopic study of the malignant cells and unusual macrophages.脑脊液中B细胞型免疫母细胞肉瘤。恶性细胞及异常巨噬细胞的光镜和电镜研究。

本文引用的文献

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Lancet. 1969 Aug 16;2(7616):367-71. doi: 10.1016/s0140-6736(69)92712-3.
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Antigens in immunity. XV. Ultrastructural features of antigen capture in primary and secondary lymphoid follicles.免疫中的抗原。十五。初级和次级淋巴滤泡中抗原捕获的超微结构特征。
J Exp Med. 1968 Feb 1;127(2):277-90. doi: 10.1084/jem.127.2.277.