Gearing M, Mirra S S, Hedreen J C, Sumi S M, Hansen L A, Heyman A
Veterans Affairs Medical Center, Atlanta, GA.
Neurology. 1995 Mar;45(3 Pt 1):461-6. doi: 10.1212/wnl.45.3.461.
This report summarizes the neuropathologic findings in the first 106 autopsies of CERAD (Consortium to Establish a Registry for Alzheimer's Disease) dementia patients diagnosed clinically as having Alzheimer's disease (AD). In 92 (87%) of the 106 cases, neuropathologists confirmed Alzheimer's disease (AD) as the primary dementing illness. Coexistent Parkinson's disease (PD) changes were present in 19 (21%) and vascular lesions of varying nature and size in 26 (28%) of these 92 AD cases. The 14 cases in which AD was not interpreted as the primary dementing illness can be divided into four major subgroups based on their neuropathology findings: PD and related pathology (n = 5), hippocampal sclerosis (n = 3), miscellaneous neurodegenerative and other disorders (n = 3), and no significant changes (n = 3). Despite the relatively high level of clinical diagnostic accuracy, further refinement of assessment batteries may facilitate distinction of non-AD dementias from AD.
本报告总结了临床诊断为阿尔茨海默病（AD）的CERAD（阿尔茨海默病注册协会）痴呆患者的前106例尸检的神经病理学发现。在106例病例中的92例（87%），神经病理学家确认阿尔茨海默病（AD）为主要的痴呆性疾病。在这92例AD病例中，19例（21%）存在共存的帕金森病（PD）改变，26例（28%）存在不同性质和大小的血管病变。根据神经病理学发现，未将AD解释为主要痴呆性疾病的14例病例可分为四个主要亚组：PD及相关病理学（n = 5）、海马硬化（n = 3）、其他神经退行性疾病和其他疾病（n = 3）以及无显著变化（n = 3）。尽管临床诊断准确性相对较高，但进一步完善评估方法可能有助于区分非AD痴呆与AD。
