Pellock J M
Department of Neurology, Medical College of Virginia, Virginia Commonwealth University, Richmond 23298.
Neurology. 1995 Mar;45(3 Suppl 2):S17-24.
The goal of epilepsy treatment is complete seizure control with minimal adverse drug reactions. Because no drug is entirely free of adverse effects, the clinician must aim for a balance between efficacy and tolerability. In approximately 40% of patients, however, monotherapy with conventional antiepileptic drugs either is not tolerated or does not provide optimal seizure control. Polypharmacy may be necessary in as many as 30% of patients. As clinicians look to new agents that may produce an overall improved quality of life, they must continue to balance efficacy and adverse effects in evaluating the usefulness of the new vs the established drugs.
癫痫治疗的目标是在药物不良反应最小的情况下实现癫痫发作的完全控制。由于没有一种药物完全没有不良反应，临床医生必须在疗效和耐受性之间寻求平衡。然而，在大约40%的患者中，使用传统抗癫痫药物进行单药治疗要么无法耐受，要么无法实现最佳的癫痫发作控制。多达30%的患者可能需要联合用药。当临床医生寻求可能改善整体生活质量的新药物时，在评估新药与现有药物的效用时，他们必须继续权衡疗效和不良反应。
