大鼠前速激肽原A启动子在PC12细胞中受多种刺激的协同作用调控。
The rat preprotachykinin-A promoter is regulated in PC12 cells by the synergistic action of multiple stimuli.
作者信息
Morrison C F, McAllister J, Lyons V, Chapman K, Quinn J P
机构信息
MRC Brain Metabolism Unit, Royal Edinburgh Hospital, UK.
出版信息
Neurosci Lett. 1994 Nov 7;181(1-2):117-20. doi: 10.1016/0304-3940(94)90573-8.
PMID:7898749
Abstract
We demonstrate in PC12 cells that although nerve growth factor, forskolin or potassium-evoked depolarisation independently induced minimal or no expression from the rat preprotachykinin-A gene (rPPT) promoter linked to a reporter gene, exposure of the cells to various combinations of these stimuli specifically activated the rPPT promoter in transient transfection assays.
摘要
我们在PC12细胞中证明，虽然神经生长因子、福斯高林或钾诱导的去极化分别诱导与报告基因相连的大鼠前速激肽原-A基因（rPPT）启动子的表达极少或无表达，但在瞬时转染试验中，将这些细胞暴露于这些刺激的各种组合下可特异性激活rPPT启动子。
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