Goldberg G R, Prentice A M
MRC Dunn Clinical Nutrition Centre, Cambridge, UK.
Nutr Rev. 1994 Jun;52(6):191-200. doi: 10.1111/j.1753-4887.1994.tb01420.x.
Recent epidemiologic studies in the United Kingdom have led to the hypothesis that adverse nutritional experiences in utero have a powerful influence on the development of degenerative diseases in adulthood. Poor fetal growth as measured by weight, length, head, chest, and abdominal circumferences is a strong predictor of hypertension, diabetes, hyperlipidemia, alteration in clotting factors, Syndrome X,* and mortality from cardiovascular and chronic obstructive airways disease. The theory of fetal origins of adult disease proposes that early defects in the development, structure, and function of organs lead to a programmed susceptibility, which interacts with later diet and environmental stresses to cause overt disease many decades after the original insult.
子宫内不良的营养经历对成年后退行性疾病的发展具有强大影响。通过体重、身长、头围、胸围和腹围衡量的胎儿生长发育不良是高血压、糖尿病、高脂血症、凝血因子改变、X综合征*以及心血管疾病和慢性阻塞性气道疾病所致死亡率的有力预测指标。成年代病胎儿起源理论认为，器官发育、结构和功能的早期缺陷会导致一种程序性易感性，这种易感性会与后期的饮食和环境压力相互作用，在最初受到损害数十年后引发显性疾病。
