Craig N M, Lueder F L, Pensler J M, Bean B S, Petrick M L, Thompson R B, Eramo L R
Department of Dermatology, Northwestern University Medical School, Chicago, Illinois.
Pediatr Dermatol. 1994 Dec;11(4):346-50. doi: 10.1111/j.1525-1470.1994.tb00103.x.
A 16-day-old premature male infant developed rapidly expanding necrotic facial plaques. Histology and cultures of tissue biopsy specimens revealed infection with Rhizopus arrhizius. The patient was treated aggressively with surgical debridement, amphotericin B, and rifampin, but had a progressive spread of the cutaneous infection and a fatal clinical course. He had gastrointestinal and pulmonary involvement on autopsy. Zygomycoses are rapidly progressive infections which generally affect immunocompromised hosts. Premature infants should be included as individuals at risk for disseminated zygomycotic disease.
一名16天大的早产男婴面部出现迅速扩大的坏死性斑块。组织活检标本的组织学检查和培养显示感染了少根根霉。患者接受了手术清创、两性霉素B和利福平的积极治疗，但皮肤感染仍进行性扩散，临床过程呈致命性。尸检发现他有胃肠道和肺部受累。接合菌病是迅速进展的感染，通常影响免疫功能低下的宿主。早产儿应被视为播散性接合菌病的高危个体。
