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Short-term toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin in laboratory animals: effects, mechanisms, and animal models.

作者信息

Pohjanvirta R, Tuomisto J

机构信息

National Public Health Institute, Department of Toxicology, Kuopio, Finland.

出版信息

Pharmacol Rev. 1994 Dec;46(4):483-549.

PMID:7899475
Abstract
摘要

相似文献

1
Short-term toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin in laboratory animals: effects, mechanisms, and animal models.2,3,7,8-四氯二苯并对二恶英对实验动物的短期毒性：影响、机制及动物模型
Pharmacol Rev. 1994 Dec;46(4):483-549.
2
2,3,7,8-Tetrachlorodibenzo-p-dioxin toxicity mechanisms.2,3,7,8-四氯二苯并对二恶英的毒性机制
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3
Influence of the Ah locus on the effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on the hepatic epidermal growth factor receptor.Ah基因座对2,3,7,8-四氯二苯并对二恶英对肝表皮生长因子受体影响的作用
Mol Pharmacol. 1991 Mar;39(3):307-13.
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Receptor-mediated toxicity and implications for risk assessment.受体介导的毒性及其对风险评估的意义。
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5
Ah receptor in mice genetically "nonresponsive" for cytochrome P4501A1 induction: cytosolic Ah receptor, transformation to the nuclear binding state, and induction of aryl hydrocarbon hydroxylase by halogenated and nonhalogenated aromatic hydrocarbons in embryonic tissues and cells.对细胞色素P4501A1诱导具有基因“无反应性”的小鼠中的芳烃受体：胞质芳烃受体、向核结合状态的转变以及胚胎组织和细胞中卤代和非卤代芳烃对芳烃羟化酶的诱导。
Mol Pharmacol. 1991 Nov;40(5):818-26.
6
Comparative genetic mechanisms of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-induced tumors.
Prog Clin Biol Res. 1990;331:177-86.
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A mechanistic model of effects of dioxin on gene expression in the rat liver.二噁英对大鼠肝脏基因表达影响的机制模型。
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How toxic is 2,3,7,8-tetrachlorodibenzodioxin to humans?2,3,7,8-四氯二苯并二恶英对人类的毒性有多大？
J Toxicol Environ Health. 1990 Aug;30(4):261-71. doi: 10.1080/15287399009531428.
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Ah receptor binding to its cognate response element is required for dioxin-mediated toxicity.二噁英介导的毒性需要芳烃受体与其同源反应元件结合。
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Ah receptor mediating induction of aryl hydrocarbon hydroxylase: detection in human lung by binding of 2,3,7,8-[3H]tetrachlorodibenzo-p-dioxin.芳烃受体介导芳烃羟化酶的诱导：通过2,3,7,8-[³H]四氯二苯并对二恶英结合在人肺中检测。
Cancer Res. 1986 Jul;46(7):3739-43.

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