Maisin J R, Vankerkom J, De Saint-Georges L, Janowski M, Lambiet-Collier M, Mattelin G, Wambersie A
Université Catholique de Louvain, Unité de Radiobiologie et de Radioprotection, Brussels, Belgium.
Radiat Res. 1995 Apr;142(1):78-84.
The possible combined effects of the initiator diethylnitrosamine (DEN)+neutrons on the induction of foci, adenomas and carcinomas in the livers of C57BL/Cnb mice were evaluated. Four groups of infant mice were treated as follows: DEN alone, neutrons alone, DEN followed by neutrons and neutrons followed by DEN. Ten mice in each group were killed at 10-week intervals over 70 weeks. The following parameters were measured: body weight, liver weight, number and size of superficial macroscopic liver lesions, and number and total surface area of the different types of microscopic liver lesions. The rate of appearance of foci increased significantly at different times when a dose of 0.125 Gy of neutrons was administered 7 days before or after a dose of 1.25 micrograms of DEN. No significant differences were observed in the total surface area of foci and/or adenomas and carcinomas when increasing doses of neutrons were given 7 days before or after the administration of 1.25 and 2.5 micrograms of DEN.
评估了引发剂二乙基亚硝胺（DEN）与中子联合作用对C57BL/Cnb小鼠肝脏中病灶、腺瘤和癌的诱导作用。将四组幼鼠进行如下处理：单独使用DEN、单独使用中子、先使用DEN后使用中子以及先使用中子后使用DEN。在70周内每隔10周处死每组中的10只小鼠。测量以下参数：体重、肝脏重量、肝脏表面宏观病变的数量和大小，以及不同类型肝脏微观病变的数量和总表面积。当在1.25微克DEN剂量之前或之后7天给予0.125 Gy的中子剂量时，病灶出现率在不同时间显著增加。当在1.25微克和2.5微克DEN给药之前或之后7天给予递增剂量的中子时，病灶和/或腺瘤及癌的总表面积未观察到显著差异。
