Maisin J R, Vankerkom J, de Saint-Georges L, Janowski M, Lambiet-Collier M, Mattelin G
Université Catholique de Louvain, Unité de Radiobiologie et de Radioprotection, Brussels, Belgium.
Radiat Res. 1993 Mar;133(3):334-9.
The possible combined effects of the initiator diethylnitrosamine (DEN) with X rays on cancer induction in C57BL/Cnb mouse liver were evaluated. Four groups of infant mice were treated as follows: with DEN alone, with X rays alone, with DEN + X rays, and with X rays + DEN. Mice in each group were killed at 10-week intervals over 70 weeks. The following parameters were measured: body weight, liver weight, number and size of macroscopic liver lesions, and number and total surface of the different types of microscopic liver lesions. The number of induced liver foci and carcinomas was found to depend essentially on the dose of DEN. X irradiation did not produce any combined effect on the induction of foci and carcinomas when given 7 days before or after DEN administration.
评估了引发剂二乙基亚硝胺（DEN）与X射线联合作用对C57BL/Cnb小鼠肝脏致癌的可能影响。将四组幼鼠进行如下处理：单独使用DEN、单独使用X射线、DEN + X射线、X射线 + DEN。每组小鼠在70周内每隔10周处死一批。测量了以下参数：体重、肝脏重量、肉眼可见肝脏病变的数量和大小，以及不同类型显微镜下肝脏病变的数量和总面积。发现诱导的肝灶和癌的数量主要取决于DEN的剂量。在给予DEN前或后7天给予X射线照射时，对肝灶和癌的诱导没有产生任何联合效应。
