Duarte Z, Gantier J C, Gayral P
Biologie et contrôle des Organismes Parasites, Faculté de Pharmacie, Université de Paris XI, Châtenay Malabry, France.
Trop Med Parasitol. 1994 Sep;45(3):209-13.
The macrofilaricidal effect of albendazole in association with ivermectin was assessed in the rodent Proechimys oris, infected with Molinema dessetae. The drug combination was given to five rodents 190 days after infection. A similar group was used as control. The doses administered were 10 mg per kg for albendazole and 0.04 mg per kg for ivermectin over five days. The histological examination of intra-peritoneal nodules done six weeks after therapy revealed a clear-cut macrofilaricidal effect. The number of dead worms was significantly higher in the treated group. The histological examination revealed a lesion pattern that was related to the drug exposure. This consisted of nodules, each containing a necrotic worm that had its morphology preserved and was surrounded by a foreign body granuloma. This lesion was only seen in the treated group. A pattern related with the spontaneous death of worms was also observed. The results obtained here show the importance that albendazole-ivermectin combination could have in human filariasis therapy. Further studies in man should be done to confirm the macrofilaricidal effect of this drug combination in human filariasis.
在感染了德氏莫利线虫的啮齿动物奥氏原鼠中评估了阿苯达唑与伊维菌素联合使用的杀成虫效果。在感染190天后，将该药物组合给予5只啮齿动物。使用一组类似的动物作为对照。在五天内，阿苯达唑的给药剂量为每千克10毫克，伊维菌素的给药剂量为每千克0.04毫克。治疗六周后对腹腔结节进行的组织学检查显示出明显的杀成虫效果。治疗组中死虫的数量明显更高。组织学检查显示出与药物暴露相关的病变模式。这包括结节，每个结节都含有一条形态保存完好且被异物肉芽肿包围的坏死虫体。这种病变仅在治疗组中可见。还观察到了与虫体自然死亡相关的模式。此处获得的结果表明阿苯达唑 - 伊维菌素组合在人类丝虫病治疗中可能具有的重要性。应在人体中进行进一步研究以证实该药物组合在人类丝虫病中的杀成虫效果。
