恶性疟原虫疟疾：其对尼日利亚正常儿童和镰状细胞病儿童某些血液学参数的影响

Plasmodium falciparum malaria: its effects on some haematological parameters in normal and sickle cell Nigerian children.

作者信息

Ayatse J O, Ekanem E E

机构信息

Department of Biochemistry, College of Medical Sciences, University of Calabar, Nigeria.

出版信息

Trop Med Parasitol. 1994 Sep;45(3):219-22.

PMID:7899791

Abstract

The effect of Plasmodium falciparum malaria on the iron status was determined in 80 children: normal children without malaria (20) and with malaria (20), and sickle cell anaemia without malaria (17) and with malaria (23). Iron status was assessed using serum transferrin, serum iron, transferrin saturation and haemoglobin. The non-malaria sickle cell anaemia (SCA) group had lower transferrin (234.0 +/- 21.0) and haemoglobin (8.1 +/- 0.4) than non-malaria normal group (260.6 +/- 17.1 mg/100 ml, and 12.5% respectively). Serum iron was higher in sickle cell anaemia (125.1 +/- 17.1) than non-malaria normals (119.2 +/- 1 microgram/100 ml). Malaria caused an increase in serum transferrin, TIBC and serum iron in both normal and SCA children; these changes were more dramatic in normal than in SCA children.

摘要

在80名儿童中确定了恶性疟原虫疟疾对铁状态的影响：无疟疾的正常儿童（20名）和患疟疾的正常儿童（20名），以及无疟疾的镰状细胞贫血儿童（17名）和患疟疾的镰状细胞贫血儿童（23名）。使用血清转铁蛋白、血清铁、转铁蛋白饱和度和血红蛋白评估铁状态。非疟疾镰状细胞贫血（SCA）组的转铁蛋白（234.0±21.0）和血红蛋白（8.1±0.4）低于非疟疾正常组（分别为260.6±17.1mg/100ml和12.5%）。镰状细胞贫血患者的血清铁（125.1±17.1）高于非疟疾正常者（119.2±1μg/100ml）。疟疾导致正常儿童和SCA儿童的血清转铁蛋白、总铁结合力（TIBC）和血清铁增加；这些变化在正常儿童中比在SCA儿童中更显著。