Mahendran R, Chee K T, Peh L H, Wong K E, Lim L
Institute of Mental Health/Woodbridge Hospital, Singapore.
Singapore Med J. 1994 Aug;35(4):390-3.
Zopiclone, a novel cyclopyrrolone compound has recently become available for the treatment of insomnia in Singapore. Pharmacodynamic and pharmacokinetic studies have shown it to be an effective hypnotic with a good safety profile and minimal side-effects. The efficacy of Zopiclone was studied in a group of patients with insomnia (n = 40). The study group comprised patients with and without a psychiatric diagnosis. About two-thirds (65%) of the patients had been on hypnotics previously without relief of the insomnia. There was improvement in the various sleep parameters studied: sleep latency, sleep duration, night awakening, sleep quality, dreams, "day-after" effects. The drug was well-tolerated and only four patients experienced minor side-effects.
佐匹克隆，一种新型环吡咯酮化合物，最近在新加坡已可用于治疗失眠症。药效学和药代动力学研究表明它是一种有效的催眠药，具有良好的安全性和极小的副作用。对一组失眠患者（n = 40）进行了佐匹克隆疗效的研究。研究组包括有和没有精神疾病诊断的患者。约三分之二（65%）的患者此前一直服用催眠药但失眠症状未得到缓解。所研究的各项睡眠参数均有改善：入睡潜伏期、睡眠时间、夜间觉醒、睡眠质量、梦境、“次日”效应。该药物耐受性良好，只有4名患者出现轻微副作用。
