Hansen T W, Sponheim S, Pedersen T, Svennevig J
Barneklinikken, Rikshospitalet, Oslo.
Tidsskr Nor Laegeforen. 1995 Feb 20;115(5):591-4.
Extracorporeal membrane oxygenation is a recent addition to our therapeutic arsenal in infants with life-threatening respiratory failure. We have treated a neonate with persistent pulmonary hypertension secondary to meconium aspiration with veno-arterial extracorporeal membrane oxygenation. Both conventional, pressure-controlled ventilation and high-frequency jet ventilation having failed, extracorporeal membrane oxygenation was life-saving for this infant. A clotting episode in the extracorporeal membrane oxygenation circuit resulted in focal as well as global ischemic changes in the brain. In spite of this complication the child was found to be normal upon neurodevelopmental evaluation at one year of age. Extracorporeal membrane oxygenation is a high-technology therapy which should probably be centralized to only one to two units in Norway. It may be life-saving for selected patients who do not respond to other forms of therapy, but the risk of sequelae is not insignificant.
体外膜肺氧合是我们治疗危及生命的呼吸衰竭婴儿的治疗手段中的新成员。我们用静脉-动脉体外膜肺氧合治疗了一名因胎粪吸入继发持续性肺动脉高压的新生儿。传统的压力控制通气和高频喷射通气均告失败，体外膜肺氧合挽救了这名婴儿的生命。体外膜肺氧合回路中的一次凝血事件导致了脑部局灶性和全身性缺血性改变。尽管出现了这一并发症，但该患儿在一岁时的神经发育评估中被发现是正常的。体外膜肺氧合是一种高科技治疗方法，在挪威可能应该仅集中于一到两个单位开展。它可能会挽救那些对其他治疗形式无反应的特定患者的生命，但后遗症风险并非微不足道。
