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[犬类癌症登记]

[Registration of canine cancer].

作者信息

Arnesen K, Gamlem H, Glattre E, Moe L, Nordstoga K

机构信息

Institutt for morfologi, genetikk og akvatisk biologi Norges veterinaerhøgskole, Oslo.

出版信息

Tidsskr Nor Laegeforen. 1995 Feb 28;115(6):714-7.

PMID:7900133
Abstract

A Norwegian Canine Cancer Registry, covering four of 19 counties, has been operative since March 1990. Until the end of April 1994 about 6,000 tumours have been registered, more than 50% of these being manifestly or potentially malignant. Among 14 selected breeds the relative risk ratio for all tumours varies with factor 35 from boxer to dunker, the boxer having the highest tumour risk. The percentage distribution of specified tumour types also varies greatly between breeds, mammary cancer constituting 59% of all neoplasms in the dachshund, but only 4% in the Bernese mountain dog. Because of the genetic diversity between breeds the dog is a suitable species for differentiation between genetically determined predisposition and environmental influences in the etiology of cancer. Epidemiological surveillance of cancer morbidity in dogs may be a useful instrument for tracing carcinogens, even in the surroundings of man.

摘要

一个覆盖19个县中4个县的挪威犬类癌症登记处自1990年3月起开始运作。到1994年4月底,已登记了约6000个肿瘤,其中超过50%明显或潜在为恶性。在14个选定品种中,所有肿瘤的相对风险比从拳师犬到邓卡德犬相差35倍,拳师犬的肿瘤风险最高。特定肿瘤类型的百分比分布在不同品种之间也有很大差异,乳腺癌在腊肠犬的所有肿瘤中占59%,而在伯恩山犬中仅占4%。由于品种之间的遗传多样性,狗是区分癌症病因中基因决定的易感性和环境影响的合适物种。对犬类癌症发病率的流行病学监测可能是追踪致癌物的有用工具,即使在人类环境中也是如此。

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