Anfinsen Kristin P, Grotmol Tom, Bruland Oyvind S, Jonasdottir Thora J
Small Animal Section, Department of Companion Animal Clinical Sciences, Norwegian School of Veterinary Science, Oslo, Norway.
Can J Vet Res. 2011 Jul;75(3):209-15.
This is one of few published population-based studies describing breed specific rates of canine primary bone tumors. Incidence rates related to dog breeds could help clarify the impact of etiological factors such as birth weight, growth rate, and adult body weight/height on development of these tumors. The study population consisted of dogs within 4 large/giant breeds; Irish wolfhound (IW), Leonberger (LB), Newfoundland (NF), and Labrador retriever (LR), born between January 1st 1989 and December 31st 1998. Questionnaires distributed to owners of randomly selected dogs--fulfilling the criteria of breed, year of birth, and registration in the Norwegian Kennel Club--constituted the basis for this retrospective, population-based survey. Of the 3748 questionnaires received by owners, 1915 were completed, giving a response rate of 51%. Forty-three dogs had been diagnosed with primary bone tumors, based upon clinical examination and x-rays. The breeds IW and LB, with 126 and 72 cases per 10 000 dog years at risk (DYAR), respectively, had significantly higher incidence rates of primary bone tumors than NF and LR (P < 0.0001). Incidence rates for the latter were 11 and 2 cases per 10 000 DYAR, respectively. Pursuing a search for risk factors other than body size/weight is supported by the significantly different risks of developing primary bone tumors between similarly statured dogs, like NF and LB, observed in this study. Defining these breed-specific incidence rates enables subsequent case control studies, ultimately aiming to identify specific etiological factors for developing primary bone tumors.
这是为数不多的已发表的基于群体的研究之一，描述了犬原发性骨肿瘤的品种特异性发病率。与犬种相关的发病率有助于阐明诸如出生体重、生长速度和成年体重/身高之类的病因因素对这些肿瘤发生发展的影响。研究群体包括1989年1月1日至1998年12月31日出生的4个大型/巨型犬种的犬；爱尔兰猎狼犬（IW）、圣伯纳犬（LB）、纽芬兰犬（NF）和拉布拉多寻回犬（LR）。分发给随机挑选的符合品种、出生年份及挪威养犬俱乐部注册标准的犬主人的调查问卷构成了这项回顾性的、基于群体的调查的基础。在主人收到的3748份调查问卷中，1915份被完成，回复率为51%。基于临床检查和X光，43只犬被诊断患有原发性骨肿瘤。IW和LB这两个品种，每10000犬年发病风险（DYAR）分别有126例和72例，其原发性骨肿瘤的发病率显著高于NF和LR（P<0.0001）。后者的发病率分别为每10000 DYAR 11例和2例。本研究中观察到，体型相似的犬如NF和LB之间发生原发性骨肿瘤的风险存在显著差异，这支持了对除体型/体重之外的风险因素进行探究。定义这些品种特异性发病率有助于后续的病例对照研究，最终目标是确定发生原发性骨肿瘤的特定病因因素。
