丹麦犬口腔恶性黑色素瘤和其他头颈部肿瘤——来自丹麦兽医癌症登记处的数据。
Oral malignant melanomas and other head and neck neoplasms in Danish dogs--data from the Danish Veterinary Cancer Registry.
机构信息
Department of Small Animal Clinical Sciences, Faculty of Life Sciences, University of Copenhagen, Dyrlaegevej 16, DK-1870 Frederiksberg C, Denmark.
出版信息
Acta Vet Scand. 2009 Dec 18;51(1):54. doi: 10.1186/1751-0147-51-54.
BACKGROUND
Head and neck cancers (HNC) are relatively common and often very serious diseases in both dogs and humans. Neoplasms originating in the head and neck region are a heterogeneous group. HNC often has an unfavourable prognosis and the proximity of the tissue structures renders extirpation of tumours with sufficient margins almost incompatible with preservation of functionality. In humans oral malignant melanoma (OMM) is extremely rare, but represents a particular challenge since it is highly aggressive as is the canine counterpart, which thus may be of interest as a spontaneous animal model.
METHODS
Canine cases entered in the Danish Veterinary Cancer Registry (DVCR) from May 15th 2005 through February 29th 2008 were included in this study. Fisher's exact test was used to compare proportions of HNC in dogs and humans as well as proportions of surgically treated cases of OMM and squamous cell carcinomas (SCC). Also the proportions of benign and malignant neoplasms of different locations in dogs were compared using Fisher's exact test.
RESULTS
A total of 1768 cases of neoplasias (679 malignant, 826 benign, 263 unknown) were submitted. Of all neoplasias HNC accounted for 7.2% (n = 128). Of these, 64 (50%) were malignant and 44 (34%) benign. The most common types of malignant neoplasia were SCC (18; 28% of malignant), OMM (13; 20% of malignant), soft tissue sarcoma (11; 17% of malignant) and adenocarcinoma (5; 11% of malignant). The most common types of benign neoplasms were adenoma (7; 16% of benign), polyps (6; 14% of benign) and fibroma (5; 11% of benign).
CONCLUSIONS
In the current study, the proportion of neoplasia in the head and neck region in dogs in Denmark was similar to other canine studies and significantly more common than in humans with a large proportion of malignancies. Spontaneous HNC in dogs thus, may serve as a model for HNC in humans.Canine OMM is a spontaneous cancer in an outbred, immune-competent large mammal population and could be a clinical model for OMM in humans.
背景
头颈部癌症（HNC）在狗和人类中都是相对常见且通常非常严重的疾病。起源于头颈部区域的肿瘤是一组异质性肿瘤。HNC 的预后通常较差，由于组织结构的临近，使得在保留功能的情况下切除有足够切缘的肿瘤几乎是不可能的。在人类中，口腔恶性黑色素瘤（OMM）极为罕见，但由于其高度侵袭性，与犬类肿瘤相似，因此可能是一种具有研究价值的自发性动物模型。
方法
本研究纳入了 2005 年 5 月 15 日至 2008 年 2 月 29 日期间丹麦兽医癌症登记处（DVCR）登记的犬病例。使用 Fisher 精确检验比较了狗和人类中 HNC 的比例、接受手术治疗的 OMM 和鳞状细胞癌（SCC）的比例。此外，还使用 Fisher 精确检验比较了不同部位良性和恶性肿瘤在狗中的比例。
结果
共提交了 1768 例肿瘤（679 例恶性，826 例良性，263 例未知）。所有肿瘤中 HNC 占 7.2%（n = 128）。其中，恶性肿瘤 64 例（50%），良性肿瘤 44 例（34%）。最常见的恶性肿瘤类型为 SCC（18 例；占恶性肿瘤的 28%）、OMM（13 例；占恶性肿瘤的 20%）、软组织肉瘤（11 例；占恶性肿瘤的 17%）和腺癌（5 例；占恶性肿瘤的 11%）。最常见的良性肿瘤类型为腺瘤（7 例；占良性肿瘤的 16%）、息肉（6 例；占良性肿瘤的 14%）和纤维瘤（5 例；占良性肿瘤的 11%）。
结论
在目前的研究中，丹麦狗的头颈部肿瘤比例与其他犬科研究相似，明显高于人类，且恶性肿瘤比例较高。因此，狗自发性 HNC 可能是人类 HNC 的模型。犬 OMM 是一种在外群、免疫功能正常的大型哺乳动物群体中自发发生的癌症，可能是人类 OMM 的临床模型。
Zotero 插件