Ema M, Kurosaka R, Amano H, Ogawa Y
National Institute of Health Sciences, Osaka Branch, Japan.
Toxicology. 1995 Feb 27;96(3):195-201. doi: 10.1016/0300-483x(94)02920-p.
The objective of this study was to further evaluate the developmental toxicity of tributyltin chloride (TBTCl) in rats. Pregnant rats were given TBTCl by gastric intubation at a dose of 25, 50 or 100 mg/kg on days 7-9, days 10-12 or days 13-15 of pregnancy. A significant increase in the incidence of post-implantation loss was found in the groups treated with TBTCl on days 7-9 at 25 and 50 mg/kg and on days 10-12 at 100 mg/kg, but not in the groups treated with TBTCl on days 13-15. No significant increase in the incidence of malformed fetuses was observed after treatment with TBTCl on days 7-9. A significant increase incidence of malformed fetuses was detected when TBTCl was given on days 10-12 at 100 mg/kg and on days 13-15 at 25, 50 and 100 mg/kg. The most predominant malformation was cleft palate. It could be concluded that the manifestation of deviant development induced by TBTCl varies with the developmental stage at the time of administration and TBTCl possesses teratogenic potential with developmental phase specificity.
本研究的目的是进一步评估三丁基氯化锡（TBTCl）对大鼠的发育毒性。在妊娠第7 - 9天、第10 - 12天或第13 - 15天，对怀孕大鼠进行胃插管给予TBTCl，剂量分别为25、50或100 mg/kg。在妊娠第7 - 9天给予25和50 mg/kg TBTCl的组以及第10 - 12天给予100 mg/kg TBTCl的组中，着床后丢失的发生率显著增加，但在第13 - 15天给予TBTCl的组中未出现这种情况。在妊娠第7 - 9天给予TBTCl后，未观察到畸形胎儿发生率显著增加。当在第10 - 12天给予100 mg/kg TBTCl以及在第13 - 15天给予25、50和100 mg/kg TBTCl时，检测到畸形胎儿发生率显著增加。最主要的畸形是腭裂。可以得出结论，TBTCl诱导的发育异常表现随给药时的发育阶段而异，并且TBTCl具有发育阶段特异性的致畸潜力。
