Harazono A, Ema M, Ogawa Y
National Institute of Health Sciences, Osaka Branch, Japan.
Toxicol Lett. 1996 Dec 31;89(3):185-90. doi: 10.1016/s0378-4274(96)03805-2.
The effect of tributyltin chloride (TBTCl) administered during early pregnancy on pregnancy maintenance was evaluated in rats. Inseminated females were orally administered TBTCl at a dose of 0, 8.1, 12.2 or 16.3 mg/kg on day 0 through day 7 of pregnancy. Females were sacrificed on day 20 of pregnancy and pregnancy outcome was determined. Pregnancy failure, which was evidenced by absence of implantation sites, was found in 0 of the 10, in 2 of the 11, in 10 of the 14 and in 10 of the 13 females at 0, 8.1, 12.2 and 16.3 mg/kg, respectively. The rate of pregnancy failure was significantly higher in the 12.2 and 16.3 mg/kg groups than that in the control group. In females with successful pregnancy, the numbers of corpora lutea, implantations and post-implantation loss per litter were comparable across all groups. No increase in the incidence of malformed fetuses was found in any TBTCl-treated groups. Thus it appears that TBTCl causes pregnancy failure after administration during very early pregnancy.
在大鼠中评估了妊娠早期给予三丁基氯化锡（TBTCl）对维持妊娠的影响。对已受精的雌性大鼠在妊娠第0天至第7天口服给予剂量为0、8.1、12.2或16.3 mg/kg的TBTCl。在妊娠第20天处死雌性大鼠并确定妊娠结局。在0、8.1、12.2和16.3 mg/kg剂量组中，未观察到着床部位的10只雌性大鼠中妊娠失败的有0只，11只中有2只，14只中有10只，13只中有10只。12.2和16.3 mg/kg剂量组的妊娠失败率显著高于对照组。在成功妊娠的雌性大鼠中，所有组每窝的黄体数、着床数和着床后损失数相当。在任何TBTCl处理组中均未发现畸形胎儿的发生率增加。因此，似乎TBTCl在妊娠极早期给药后会导致妊娠失败。
