色氨酸合成酶。结构、功能与蛋白质工程 - Suppr

Tryptophan synthase. Structure, function, and protein engineering.

作者信息

Miles E W

机构信息

Enzyme Structure and Function Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892.

出版信息

Subcell Biochem. 1995;24:207-54.

PMID:7900177

Abstract

摘要

相似文献

Tryptophan synthase. Structure, function, and protein engineering.色氨酸合成酶。结构、功能与蛋白质工程

Subcell Biochem. 1995;24:207-54.

The molecular biology of tryptophan synthase: a model for protein-protein interaction.

Biotechnol Genet Eng Rev. 1991;9:229-94.

Mutagenic analysis of the interior packing of an alpha/beta barrel protein. Effects on the stabilities and rates of interconversion of the native and partially folded forms of the alpha subunit of tryptophan synthase.α/β桶状蛋白内部包装的诱变分析。对色氨酸合酶α亚基天然形式和部分折叠形式的稳定性及相互转化速率的影响。

Biochemistry. 1993 Jun 1;32(21):5566-75. doi: 10.1021/bi00072a011.

Conformational changes in the alpha-subunit coupled to binding of the beta 2-subunit of tryptophan synthase from Escherichia coli: crystal structure of the tryptophan synthase alpha-subunit alone.与大肠杆菌色氨酸合酶β2亚基结合相关的α亚基构象变化：单独的色氨酸合酶α亚基的晶体结构

Biochemistry. 2005 Feb 1;44(4):1184-92. doi: 10.1021/bi047927m.

Exchange of K+ or Cs+ for Na+ induces local and long-range changes in the three-dimensional structure of the tryptophan synthase alpha2beta2 complex.用K⁺或Cs⁺替换Na⁺会诱导色氨酸合酶α2β2复合物三维结构发生局部和远距离变化。

Biochemistry. 1996 Apr 2;35(13):4211-21. doi: 10.1021/bi952506d.

Structural basis for catalysis by tryptophan synthase.

Adv Enzymol Relat Areas Mol Biol. 1991;64:93-172. doi: 10.1002/9780470123102.ch3.

Directed evolution of (βα)(8)-barrel enzymes: establishing phosphoribosylanthranilate isomerisation activity on the scaffold of the tryptophan synthase α-subunit.（βα）（8）桶状酶的定向进化：在色氨酸合酶α亚基的支架上建立磷酸核糖基氨基苯甲酸异构酶活性。

Protein Eng Des Sel. 2012 Jun;25(6):285-93. doi: 10.1093/protein/gzs015. Epub 2012 Apr 6.

Ligand-mediated changes in the tryptophan synthase indole tunnel probed by nile red fluorescence with wild type, mutant, and chemically modified enzymes.通过尼罗红荧光对野生型、突变型和化学修饰酶的色氨酸合酶吲哚通道中配体介导的变化进行探测。

J Biol Chem. 1995 Mar 17;270(11):6357-69. doi: 10.1074/jbc.270.11.6357.

Conformational changes and subunit communication in tryptophan synthase: effect of substrates and substrate analogs.色氨酸合成酶的构象变化与亚基通讯：底物及底物类似物的影响

Biochemistry. 1992 Aug 25;31(33):7535-42. doi: 10.1021/bi00148a014.

beta-Site covalent reactions trigger transitions between open and closed conformations of the tryptophan synthase bienzyme complex.β位点共价反应触发色氨酸合酶双酶复合物开放和闭合构象之间的转变。

Biochemistry. 1996 Apr 16;35(15):5002-13. doi: 10.1021/bi960033k.

引用本文的文献

Light-Regulation of Tryptophan Synthase by Combining Protein Design and Enzymology.光调控色氨酸合酶的蛋白质设计与酶学研究

Int J Mol Sci. 2019 Oct 15;20(20):5106. doi: 10.3390/ijms20205106.

Genetic Transformation of a Ocular Isolate With the Functional Tryptophan Synthase Operon Confers an Indole-Rescuable Phenotype.用具有功能色氨酸合成酶操纵子的眼部分离物进行遗传转化赋予吲哚可挽救表型。

Front Cell Infect Microbiol. 2018 Dec 14;8:434. doi: 10.3389/fcimb.2018.00434. eCollection 2018.

Gene Deletion by Fluorescence-Reported Allelic Exchange Mutagenesis in Chlamydia trachomatis.通过荧光报告等位基因交换诱变在沙眼衣原体中进行基因缺失

mBio. 2016 Jan 19;7(1):e01817-15. doi: 10.1128/mBio.01817-15.

The role of oligomerization and cooperative regulation in protein function: the case of tryptophan synthase.寡聚化和协同调节在蛋白质功能中的作用：色氨酸合酶的案例。

PLoS Comput Biol. 2010 Nov 11;6(11):e1000994. doi: 10.1371/journal.pcbi.1000994.

Tryptophan synthase: a mine for enzymologists.色氨酸合成酶：酶学家的宝库。

Cell Mol Life Sci. 2009 Jul;66(14):2391-403. doi: 10.1007/s00018-009-0028-0. Epub 2009 Apr 22.

The favorable features of tryptophan synthase for proving Beadle and Tatum's one gene-one enzyme hypothesis.色氨酸合成酶有利于证明比德尔和塔特姆的“一个基因一种酶”假说。

Genetics. 2005 Feb;169(2):511-6. doi: 10.1093/genetics/169.2.511.

C-terminal hydrophobic interactions play a critical role in oligomeric assembly of the P22 tailspike trimer.C 末端疏水相互作用在 P22 尾刺三聚体的寡聚组装中起关键作用。

Protein Sci. 2003 Dec;12(12):2732-47. doi: 10.1110/ps.03150303.

Polymorphisms in Chlamydia trachomatis tryptophan synthase genes differentiate between genital and ocular isolates.沙眼衣原体色氨酸合成酶基因多态性可区分生殖道分离株和眼部分离株。

J Clin Invest. 2003 Jun;111(11):1757-69. doi: 10.1172/JCI17993.

The effect of different amino acid side chains on the stereospecificity and catalytic efficiency of the tryptophan synthase-catalysed exchange of the alpha-protons of amino acids.不同氨基酸侧链对色氨酸合酶催化氨基酸α-质子立体特异性和催化效率的影响。

Biochem J. 1996 Mar 15;314 ( Pt 3)(Pt 3):787-91. doi: 10.1042/bj3140787.

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Tryptophan synthase. Structure, function, and protein engineering.

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